Sodium Thiosulfate (sodium thiosulfate)
Cyanide Poisoning Antidotes Intravenous Vial (ML)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Sodium thiosulfate is a cyanide antidote.
Generic name: sodium thiosulfate
Drug class: Cyanide Poisoning Antidotes
Therapeutic class: Antidotes and other Reversal Agents
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Sodium Thiosulfate
Indications
The following indications are listed for Sodium Thiosulfate:
- Cyanide Toxicity
Also known as: Cyanide Intoxication.
Dosing
It isessential that the manufacturer's labeling be consulted for more detailed information on dosage and administration of this drug. Dosage summary:
No dosing information is available for this tab.
| Drug label | Dosing type | Instructions |
|---|---|---|
| Sodium Thiosulfat 12.5 G/50 Ml | Maintenance | Infuse 12.5 gram over 10-30 minute(s) by intravenous route x1 dose. |
| Drug label | Dosing type | Instructions |
|---|---|---|
| Sodium Thiosulfat 12.5 G/50 Ml | Maintenance | Infuse 12.5 gram over 10-30 minute(s) by intravenous route x1 dose. |
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
*None.
- Lactation
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
Most common adverse reactions are hypotension, headache, and disorientation.
More Frequent
- Hypotension
Less Frequent
- Increased risk of bleeding
More Frequent
- Acute cognitive impairment
- Headache disorder
Less Frequent
- Dysgeusia
- Nausea
- Sensation of warmth
- Vomiting
Precautions
No enhanced messaging available.
There are case reports in the medical literature of sodium nitrite in conjunction with sodium thiosulfate being administered to pediatric patients with cyanide poisoning; however, there have been no clinical studies to evaluate the safety or efficacy of sodium thiosulfate in the pediatric population.
There are no available data on sodium thiosulfate use in pregnant women to evaluate for a drug-associated risk.
There are risks to the pregnant woman and fetus associated with untreated cyanide poisoning. Therefore, if a pregnant woman has known or suspected cyanide poisoning, sodium thiosulfate injection for sequential use with sodium nitrite is recommended.
In published animal studies, no evidence of embryotoxicity or malformations was reported when sodium thiosulfate was administered during organogenesis to pregnant mice, rats, hamsters, or rats at 0.2 to 0.9 times the human daily dose of 12.5 g for cyanide poisoning. The studies did not test doses that were comparable to the human dose for cyanide poisoning.
Because of the potential for serious adverse reactions in the breastfed infant, the manufacturer of the sodium thiosulfate preparation indicated for acute cyanide poisoning states that breastfeeding is not recommended during treatment with the drug. There are no data to determine when breastfeeding may be safely restarted following the administration of sodium thiosulfate.
No enhanced messaging available.
ICD codes
| Code | Type | Description |
|---|---|---|
| Cyanide toxicity | ||
| T57.3x1A | ICD10CM | Toxic effect of hydrogen cyanide, accidental (unintentional), initial encounter |
| T57.3x2A | ICD10CM | Toxic effect of hydrogen cyanide, intentional self-harm, initial encounter |
| T57.3x3A | ICD10CM | Toxic effect of hydrogen cyanide, assault, initial encounter |
| T57.3x4A | ICD10CM | Toxic effect of hydrogen cyanide, undetermined, initial encounter |
| T65.0x1A | ICD10CM | Toxic effect of cyanides, accidental (unintentional), initial encounter |
| T65.0x2A | ICD10CM | Toxic effect of cyanides, intentional self-harm, initial encounter |
| T65.0x3A | ICD10CM | Toxic effect of cyanides, assault, initial encounter |
| T65.0x4A | ICD10CM | Toxic effect of cyanides, undetermined, initial encounter |
ICD code information from First Databank (FDB).
Formulary status
Search health-plan coverage for this drug by ZIP code.
Choose the first character of a health plan name.
Last reviewed · Source: First Databank (FDB) drug data
On this page
Actions
Sign in to save favorites
Saving this drug requires a free Physicians Office Resource account.