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Ampicillin Sodium (ampicillin sodium)

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Last reviewed · Source: First Databank (FDB) drug data

Overview

Ampicillin is an aminopenicillin antibiotic.

Ampicillin shares the uses of other aminopenicillins and is used principally for the treatment of infections caused by susceptible gram-negative bacteria (e.g., Haemophilus influenzae, Escherichia coli, Proteus mirabilis, Salmonella). Ampicillin also is used for the treatment of infections caused by susceptible gram-positive bacteria (e.g., Streptococcus pneumoniae, enterococci, nonpenicillinase-producing staphylococci, Listeria); however, like other aminopenicillins, ampicillin generally should not be used for the treatment of streptococcal or staphylococcal infections when a natural penicillin would be effective. Orally administered ampicillin should not be used for the initial treatment of severe, life-threatening infections, but may be used as follow-up therapy after parenteral ampicillin therapy.

For specific information on the uses of ampicillin, see Uses in the Aminopenicillins General Statement 8:12.16.08.

Generic name: ampicillin sodium
Pronunciation: (AM-pi-SIL-in)

Reference product & biosimilars

No reference, biosimilar or interchangeable associated with this drug.

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Indications

The following indications are listed for Ampicillin Sodium:

  • Acute Epiglottitis
  • Acute Streptococcal Epiglottitis
  • Bacterial Endocarditis
  • Bacterial Meningitis
  • Bacterial Pneumonia
  • Bacterial Sepsis
  • Bacterial Urinary Tract Infection
  • Cesarean Section Infection Prevention
  • Chronic Bronchitis With Bacterial Exacerbation
  • E. Coli Septicemia
  • Enterococcal Endocarditis
  • Enterococcus Septicemia
  • Escherichia Coli Meningitis
  • Gastroenteritis Due To Salmonella
  • Gastroenteritis Due To Shigella
  • Genitourinary Tract Infections
  • Haemophilus Influenzae Pneumonia
  • Infection Prevention For Gi Surgery
  • Meningococcal Meningitis
  • Neonatal Group B Streptococcal Septicemia
  • Pneumococcal Meningitis
  • Proteus Septicemia
  • Salmonella Septicemia
  • Skin And Skin Structure Infection
  • Staphylococcal Pneumonia
  • Staphylococcus Aureus Septicemia
  • Streptococcal Endocarditis
  • Streptococcal Pneumonia
  • Streptococcal Septicemia
  • Tonsillitis Due To Streptococcus Pyogenes
  • Typhoid Fever
  • Vaginal Hysterectomy Infection Prevention

Also known as: Acute Bacterial Exacerbation Of Chronic Bronchitis, Acute Epiglottiditis, Bacillary Dysentery From Shigella Spp., Bacteremia With Sepsis, Bacterial Exacerbation Of Chronic Bronchitis, Bacterial Septicemia, E. Coli Sepsis, Endocarditis Due To Enterococcus, Endocarditis Due To Streptococcus, Escherichia Coli Sepsis, Escherichia Coli Septicemia, Gastroenteritis Due To Salmonella Spp., Gastroenteritis Due To Shigella Species, Genitourinary Infection, Genitourinary Tract Infection, H. Flu Pneumonia, H. Influenzae Pneumonia, Hemophilus Influenzae Pneumonia, Infection Of Skin And/Or Subcutaneous Tissue, Infection Prophylaxis For C-Section, Infection Prophylaxis For Cesarean Section, Infection Prophylaxis For Gastrointestinal Surgery, Infection Prophylaxis For Vaginal Hysterectomy, Influenza Bacillus Pneumonia, Intestinal Shigella Infection, Neonatal Group B Streptococcal Sepsis, Pfeiffer's Bacillus Pneumonia, Pneumonia Due To Haemophilus Influenzae, Pneumonia Due To Staphylococcus Species, Pneumonia Due To Staphylococcus Spp., Pneumonia Due To Streptococcus Species, Pneumonia Due To Streptococcus Spp., Salmonella Food Poisoning, Salmonella Gastroenteritis, Salmonella Sepsis, Sepsis Due To Enterococcus, Sepsis Due To Proteus Species, Sepsis Due To Staphylococcus Aureus, Septicemia Due To Enterococcus, Septicemia Due To Proteus Species, Septicemia Due To Proteus Spp., Septicemia Due To Staph Aureus, Septicemia Due To Staphylococcus Aureus, Shigellosis, Skin And Soft Tissue Skin Infection, Streptococcal Epiglottiditis, Streptococcal Sepsis, Streptococcus Pneumoniae Meningitis, Streptococcus Pyogenes Tonsillitis.

Dosing

Dosage of ampicillin sodium and ampicillin trihydrate is expressed in terms of ampicillin.

The manufacturers' dosage recommendations for adults usually are the same for both parenteral and oral routes; however, higher serum concentrations usually are attained parenterally, and this route is used for severe infections.

In patients with renal impairment, doses and/or frequency of administration of ampicillin should be modified in response to the degree of renal impairment, severity of the infection, and susceptibility of the causative organism. Some clinicians suggest that adults with glomerular filtration rates of 10-50 mL/minute receive the usual dose of ampicillin every 6-12 hours and that adults with glomerular filtration rates less than 10 mL/minute receive the usual dose every 12-16 hours. Alternatively, some clinicians suggest that modification of usual dosage of ampicillin is unnecessary in adults with creatinine clearances of 30 mL/minute or greater, but adults with creatinine clearances of 10 mL/minute or less should receive the usual dose of the drug every 8 hours.

Patients undergoing hemodialysis should receive a supplemental dose of ampicillin after each dialysis period.

Drug interactions

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Contraindications

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Adverse reactions

There is no enhanced messaging for this drug.

Precautions

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ICD codes

No ICD codes are available for this drug.

Formulary status

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Last reviewed · Source: First Databank (FDB) drug data