Trazodone (trazodone HCl)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Trazodone hydrochloride is a triazolopyridine-derivative antidepressant that is chemically and structurally unrelated to tricyclic or tetracyclic antidepressants or to selective serotonin-reuptake inhibitors.
USES: This medication is used to treat depression. Trazodone works by helping to restore the balance of a certain natural substance (serotonin) in the brain.
Generic name: trazodone HCl
Pronunciation: (TRAZ-oh-done)
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Trazodone
Indications
The following indications are listed for Trazodone:
- Major Depressive Disorder
Also known as: Major Unipolar Illness, Unipolar Mood Disorder.
Dosing
There is a wide range of individual trazodone hydrochloride dosage requirements, and dosage must be carefully adjusted according to individual tolerance and response, using the lowest possible effective dosage.
Patients receiving trazodone should be monitored for possible worsening of depression, suicidality, or unusual changes in behavior, especially at the beginning of therapy or during periods of dosage adjustment. (See Cautions: Precautions and Contraindications.)
Trazodone hydrochloride is administered orally. The drug should be taken shortly after a meal or light snack. If drowsiness occurs, a major portion of the daily dose may be given at bedtime or dosage may be reduced.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
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No enhanced messaging available.
Trazodone has been shown to be teratogenic in rats and rabbits when given at dosages 15-50 times the maximum human dosage. The drug also caused increased fetal resorption and other adverse fetal effects in rats when given at dosages approximately 30-50 times the suggested maximum human dosage. There are no adequate and controlled studies to date using trazodone in pregnant women, and the drug should be used during pregnancy only when the potential benefits justify the possible risks to the fetus.
Because trazodone is distributed into milk, the drug should be used with caution in nursing women.
No enhanced messaging available.
ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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