Chlorhexidine Gluconate (chlorhexidine gluconate)
Mucous Membrane Mouthwash
Last reviewed · Source: First Databank (FDB) drug data
Overview
Chlorhexidine gluconate, a cationic bisbiguanide, is a topical anti-infective agent.
Chlorhexidine gluconate 0.12% topical oral solution is used as a mouthwash or oral rinse for the treatment of gingivitis. Chlorhexidine gluconate, as a subgingival preparation containing the drug in a biodegradable extended-release insert, is used as an adjunct in the treatment of adult periodontitis.
Generic name: chlorhexidine gluconate
Pronunciation: (khlor-HEX-i-deen GLOO-koe-nate)
Therapeutic class: Mouth-Throat-Dental - Preparations
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Chlorhexidine Gluconate
Indications
The following indications are listed for Chlorhexidine Gluconate:
- Gingivitis
- Mouth Infection Prevention
Also known as: Mouth Infection Prophylaxis.
Dosing
Dosage of chlorhexidine gluconate is expressed in terms of the salt.
No dosing information is available for this tab.
| Drug label | Dosing type | Instructions |
|---|---|---|
| Chlorhexidine 0.12% 15 Ml Cup | Maintenance | Place 15 milliliters in the mouth by mucous membrane route 2 times per day (after meals), swish in mouth for 30 seconds then spit out. |
| Drug label | Dosing type | Instructions |
|---|---|---|
| Chlorhexidine 0.12% Rinse | Maintenance | Place 15 milliliters in the mouth by mucous membrane route 2 times per day (after meals), swish in mouth for 30 seconds then spit out. |
| Chlorhexidine 0.12% 15 Ml Cup | Maintenance | Place 15 milliliters in the mouth by mucous membrane route 2 times per day (after meals), swish in mouth for 30 seconds then spit out. |
| Chlorhexidine 0.12% 10 Ml Cup | Maintenance | Place 15 milliliters in the mouth by mucous membrane route 2 times per day (after meals), swish in mouth for 30 seconds then spit out. |
| Chlorhexidine 0.12% 30 Ml Cup | Maintenance | Place 15 milliliters in the mouth by mucous membrane route 2 times per day (after meals), swish in mouth for 30 seconds then spit out. |
| Chlorhexidine 0.12% 5 Ml Cup | Maintenance | Place 15 milliliters in the mouth by mucous membrane route 2 times per day (after meals), swish in mouth for 30 seconds then spit out. |
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
- Periodontitis
Adverse reactions
There is no enhanced messaging for this drug.
Rare or Very Rare
- Allergic dermatitis
- Anaphylaxis
- Angioedema
- Sialoadenitis
More Frequent
- Dental discoloration
- Dysgeusia
- Increased tartar formation
- Mouth discoloration
Rare or Very Rare
- Aphthous stomatitis
- Erythema of mouth mucous membrane
- Glossitis
- Mouth irritation
- Oral hypoesthesia
- Parotitis
- Sore tongue
- Xerostomia
Precautions
No enhanced messaging available.
No enhanced messaging available.
Reproduction studies in rats or rabbits using chlorhexidine gluconate given by gastric lavage in daily dosages up to 300 or 40 mg/kg, respectively, have not revealed evidence of harm to the fetus. Animal reproduction studies have not been performed with commercially available chlorhexidine gluconate inserts for subgingival administration because animal models that would permit use of a clinically relevant route of administration are not available.
There are no adequate and controlled studies to date using chlorhexidine gluconate in pregnant women, and chlorhexidine gluconate topical oral solution and subgingival chlorhexidine gluconate inserts should be used during pregnancy only when clearly needed.
Although systemic absorption of chlorhexidine does not appear to occur following use of chlorhexidine gluconate topical oral solution or subgingival chlorhexidine gluconate inserts, it is not known whether the drug would be distributed into milk if systemic absorption were to occur. Therefore, chlorhexidine gluconate preparations should be used with caution in nursing women.
In studies in rats, there was no evidence of impaired parturition or toxic effects to suckling pups when chlorhexidine gluconate was administered to dams at dosages that were more than 100 times greater than that which would occur if a person ingested 30 mL of 0.12% chlorhexidine gluconate topical oral solution daily.
No enhanced messaging available.
ICD codes
| Code | Type | Description |
|---|---|---|
| Gingivitis | ||
| K05.0 | ICD10CM | Acute gingivitis |
| K05.00 | ICD10CM | Acute gingivitis, plaque induced |
| K05.01 | ICD10CM | Acute gingivitis, non-plaque induced |
| K05.1 | ICD10CM | Chronic gingivitis |
| K05.10 | ICD10CM | Chronic gingivitis, plaque induced |
| K05.11 | ICD10CM | Chronic gingivitis, non-plaque induced |
ICD code information from First Databank (FDB).
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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