Nuzolvence (zoliflodacin)
Oral Granules In Packet (Ea)
Last reviewed · Source: First Databank (FDB) drug data
Overview
USES: Zoliflodacin is used to treat a certain genital infection (gonorrhea). This medication is an antibiotic. It works by stopping the growth of bacteria.
This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.
Generic name: zoliflodacin
Pronunciation: (ZOE-li-floe-DAY-sin)
Therapeutic class: Anti-Infective Agents
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Nuzolvence
Indications
The following indications are listed for Nuzolvence:
- Acute Lower Genitourinary Gonorrhea
Also known as: Acute Lower Genitourinary Tract Gonococcal Infection, Acute Lower Genitourinary Tract Gonorrhea, Acute Lower Gu Tract Neisseria Gonorrhoeae Infection.
Dosing
No dosing information is available for this tab.
No dosing information is available for this tab.
| Drug label | Dosing type | Instructions |
|---|---|---|
| Nuzolvence 3 Gram Packet | Maintenance | Take 1 packet (3 gram) by oral route once mixed with 60 mL water in provided container, shake vigorously 60 seconds; take within 15 minutes. |
No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
Contraindicated Drug Combination: This drug combination is contraindicated and generally should not be dispensed or administered to the same patient.
Zoliflodacin/Moderate Cyp3a4 Inducers
SEVERITY LEVEL: 1-Contraindicated Drug Combination: This drug combination is contraindicated and generally should not be dispensed or administered to the same patient.
MECHANISM OF ACTION: Zoliflodacin is a CYP3A4 substrate. Moderate CYP3A4 inducers may induce the metabolism of zoliflodacin.(1)
CLINICAL EFFECTS: Concurrent or recent use of a moderate inducer of CYP3A4 may decrease the levels and effectiveness of zoliflodacin.(1)
PREDISPOSING FACTORS: Induction effects may be more likely with regular use of the inducer for longer than 1-2 weeks.
PATIENT MANAGEMENT: The manufacturer of zoliflodacin states that co-administration with moderate inducers of CYP3A4 is contraindicated.(1)
DISCUSSION: Efavirenz, a moderate CYP3A4 inducer, is predicted to decrease the area-under-curve (AUC) of zoliflodacin by approximately 41%.(1) Moderate CYP3A4 inducers linked to this monograph include: belzutifan, bosentan, cenobamate, dabrafenib, dipyrone, efavirenz, elagolix, etravirine, fexinidazole, lesinurad, lorlatinib, mavacamten, mitapivat, modafinil, nafcillin, pacritinib, pexidartinib, repotrectinib, rifabutin, sotorasib, telotristat ethyl, thioridazine, and tovorafenib.(2,3)
Zoliflodacin/Strong Cyp3a4 Inducers
SEVERITY LEVEL: 1-Contraindicated Drug Combination: This drug combination is contraindicated and generally should not be dispensed or administered to the same patient.
MECHANISM OF ACTION: Zoliflodacin is a CYP3A4 substrate. Strong CYP3A4 inducers may induce the metabolism of zoliflodacin.(1)
CLINICAL EFFECTS: Concurrent or recent use of a strong inducer of CYP3A4 may decrease the levels and effectiveness of zoliflodacin.(1)
PREDISPOSING FACTORS: Induction effects may be more likely with regular use of the inducer for longer than 1-2 weeks.
PATIENT MANAGEMENT: The manufacturer of zoliflodacin states that co-administration with strong inducers of CYP3A4 is contraindicated.(1)
DISCUSSION: Rifampin, a strong CYP3A4 inducer, is predicted to decrease the area-under-curve (AUC) of zoliflodacin by approximately 56%.(1) Strong CYP3A4 inducers linked to this monograph include: apalutamide, barbiturates, carbamazepine, encorafenib, enzalutamide, fosphenytoin, ivosidenib, lumacaftor, mitotane, phenobarbital, phenytoin, primidone, rifampin, rifapentine, and St. John's Wort.(2,3)
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
There are no contraindication contraindications for this drug.
- Clostridioides difficile infection
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
There are no severe adverse reactions for this drug.
More Frequent
- Diarrhea
- Dizziness
- Headache disorder
- Leukopenia
- Nausea
- Neutropenic disorder
Less Frequent
- Abdominal distension
- Abnormal hepatic function tests
- Abnormal vasomotor function
- Acute abdominal pain
- Alopecia
- Anemia
- Candidiasis
- Chills
- Constipation
- Cough
- Dermatophytosis
- Drowsy
- Eyelid edema
- Fatigue
- Fever
- Flatulence
- General weakness
- Hematuria
- Hypersomnia
- Hypoesthesia
- Insomnia
- Kidney disease with reduction in glomerular filtration rate (GFr)
- Malaise
- Musculoskeletal pain
- Night sweats
- Palpitations
- Pruritus of skin
- Skin rash
- Thrombocytopenic disorder
- Vomiting
Precautions
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
ICD codes
| Code | Type | Description |
|---|---|---|
| Acute lower genitourinary gonorrhea | ||
| A54.0 | ICD10CM | Gonococcal infection of lower genitourinary tract without periurethral or accessory gland abscess |
| A54.00 | ICD10CM | Gonococcal infection of lower genitourinary tract, unspecified |
| A54.01 | ICD10CM | Gonococcal cystitis and urethritis, unspecified |
| A54.02 | ICD10CM | Gonococcal vulvovaginitis, unspecified |
| A54.03 | ICD10CM | Gonococcal cervicitis, unspecified |
| A54.09 | ICD10CM | Other gonococcal infection of lower genitourinary tract |
| A54.1 | ICD10CM | Gonococcal infection of lower genitourinary tract with periurethral and accessory gland abscess |
ICD code information from First Databank (FDB).
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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