Cosmegen (dactinomycin)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Dactinomycin is an antineoplastic antibiotic obtained as the principal component of the mixture of actinomycins produced by Streptomyces parvullus.
USES: Dactinomycin is used to treat cancer. It works by slowing or stopping the growth of cancer cells.
Generic name: dactinomycin
Pronunciation: (dack-tin-oh-MY-sin)
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Cosmegen
Indications
The following indications are listed for Cosmegen:
- Ewing's Sarcoma
- Gestational Trophoblastic Neoplasia
- Refractory Malignant Tumor Of Testis
- Rhabdomyosarcoma
- Wilms' Tumor
Also known as: Embryoma Of Kidney, Embryonal Adenomyosarcoma, Embryonal Adenosarcoma, Embryonal Carcinosarcoma, Embryonal Nephroma, Ewing's Tumor, Mesoblastic Nephroma, Nephroblastoma, Refractory Testicular Cancer, Renal Carcinosarcoma, Rhabdomyoblastoma, Rhabdosarcoma, Trophoblastic Neoplasm.
Dosing
Dosage of dactinomycin should be calculated carefully before administration of each dose. Dosage of dactinomycin must be based on the clinical and hematologic response and tolerance of the patient and whether other chemotherapy or radiation therapy has been or is also being used in order to obtain optimum therapeutic results with minimum adverse effects. Dosage should be based on body surface area in obese or edematous patients. If radiation therapy or other chemotherapy is used concomitantly with or prior to dactinomycin, the dosage of dactinomycin may need to be reduced. Clinicians should consult published protocols for the dosage of dactinomycin and other chemotherapeutic agents and the method and sequence of administration. Dosing and administration of dactinomycin should be performed under the direct supervision of clinicians familiar with current oncologic practices and new advances in therapy.
Dactinomycin IV dosage for each 2-week course of therapy in adults or children should not exceed 15 mcg/kg daily or 400-600 mcg/m2 daily for 5 days.
No dosing information is available for this tab.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
No enhanced messaging available.
No enhanced messaging available.
Dactinomycin can cause fetal toxicity when administered to pregnant women, but potential benefits from use of the drug may be acceptable in certain conditions despite the possible risks to the fetus. Dactinomycin has been shown to be teratogenic and embryotoxic in rats, rabbits, and hamsters when given IV at doses approximately 0.5-2 times the maximum recommended human dose. Women of child-bearing potential should be advised to avoid becoming pregnant while receiving dactinomycin, and the drug should be used during pregnancy only in life-threatening situations or severe disease for which safer drugs cannot be used or are ineffective. When the drug is administered during pregnancy or if the patient becomes pregnant while receiving the drug, the patient should be informed of the potential hazard to the fetus.
It is not known if dactinomycin is distributed into milk. Because of the potential for serious adverse reactions to dactinomycin in nursing infants, a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the woman.
No enhanced messaging available.
ICD codes
No ICD codes are available for this drug.
Formulary status
Search health-plan coverage for this drug by ZIP code.
Choose the first character of a health plan name.
Last reviewed · Source: First Databank (FDB) drug data
On this page
Actions
Sign in to save favorites
Saving this drug requires a free Physicians Office Resource account.