Prednisolone Acetate (prednisolone acetate)
Ophthalmic Steroids Ophthalmic (Eye) Suspension, Drops(Final Dosage Form)(Ml)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Prednisolone is a synthetic corticosteroid.
USES: This medication is used to treat certain eye conditions due to inflammation or injury. Prednisolone works by relieving symptoms such as swelling, redness, and itching. It belongs to a class of drugs known as corticosteroids.
Generic name: prednisolone acetate
Pronunciation: (pred-NIS-oh-loan)
Drug class: Ophthalmic Steroids
Therapeutic class: Ophthalmic Agents
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Prednisolone Acetate
Indications
The following indications are listed for Prednisolone Acetate:
- Severe Ocular Inflammation
Also known as: Severe Ophthalmic Inflammation.
Dosing
Potency of some sodium phosphate preparations is expressed in terms of prednisolone phosphate.
For use in the eye, 1 or 2 drops of prednisolone acetate ophthalmic suspension or prednisolone sodium phosphate ophthalmic solution may be instilled into the conjunctival sac every hour during the day and every 2 hours during the night for initial therapy in severe cases. In mild or moderate inflammation or when a favorable response is attained in severe cases, dosage may be reduced to 1 or 2 drops every 3-12 hours.
Alternatively, prednisolone sodium phosphate ophthalmic ointment may be instilled into the conjunctival sac 3 or 4 times daily initially, and once or twice daily thereafter. The ointment also may be used at night in conjunction with daytime use of a suspension or solution to reduce the frequent applications required with the liquid dosage forms.
The lowest effective concentration should be used and, if improvement does not occur within several days, the drug should be discontinued and other therapy begun. The duration of treatment depends on the type and severity of the disease and may range from a few days to several weeks; long-term therapy should be avoided. When the drug is discontinued, dosage should be gradually tapered to avoid exacerbation of the disease.
Prednisolone acetate or sodium phosphate is applied topically to the eye. Care should be taken to avoid contamination of the tip of the ointment tube or dropper when the drug is used ophthalmically.
| Drug label | Dosing type | Instructions |
|---|---|---|
| Prednisolone Ac 1% Eye Drop | Maintenance | Instill 1 drop into affected eye(s) by ophthalmic route 2 times per day. |
| Drug label | Dosing type | Instructions |
|---|---|---|
| Prednisolone Ac 1% Eye Drop | Maintenance | Instill 1 drop into affected eye(s) by ophthalmic route 2 times per day. |
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
- Fungal infection of eye
- Herpes simplex dendritic keratitis
- Tuberculosis of the eye
- Vaccinia virus keratitis
- Amebic infection of the eye
- Ocular hypertension
- Corneal erosion
- Diabetes mellitus
- Krukenberg spindle
- Open angle glaucoma
- Severe myopia
Adverse reactions
There is no enhanced messaging for this drug.
Less Frequent
- Ocular hypertension
Rare or Very Rare
- Adrenocortical insufficiency
- Cataracts
- Central serous chorioretinopathy
- Corneal degeneration
- Corneal edema
- Corneal erosion
- Corneal ulcer
- Fungal infection of eye
- Glaucoma
- Globe perforation
- Hypercortisolism
- Hypersensitivity drug reaction
- Keratitis
- Optic nerve damage
- Punctate keratitis
- Reduced visual acuity
- Uveitis
- Visual changes
- Visual field defect
More Frequent
- Blurred vision
Less Frequent
- Headache disorder
- Iritis
- Ocular pain
Rare or Very Rare
- Accommodation disorder
- Allergic dermatitis
- Blepharoptosis
- Calcification of cornea
- Chemosis
- Conjunctival hyperemia
- Conjunctivitis
- Dizziness
- Dysgeusia
- Eye tearing
- Foreign body sensation of eye
- Impaired wound healing
- Mydriasis
- Ocular infection
- Ocular irritation
- Ocular itching
- Ocular redness
- Photophobia
- Urticaria
Precautions
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
ICD codes
| Code | Type | Description |
|---|---|---|
| Severe ocular inflammation | ||
| H57.8 | ICD10CM | Other specified disorders of eye and adnexa |
| H57.89 | ICD10CM | Other specified disorders of eye and adnexa |
ICD code information from First Databank (FDB).
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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