Pyrazinamide (pyrazinamide)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Pyrazinamide, a derivative of niacinamide, is a synthetic antituberculosis agent.
USES: Pyrazinamide is used with other medications to treat tuberculosis (TB). It is an antibiotic and works by stopping the growth of bacteria. This antibiotic treats only bacterial infections.
It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.
Generic name: pyrazinamide
Pronunciation: (pir-uh-ZIN-uh-mide)
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Pyrazinamide
Indications
The following indications are listed for Pyrazinamide:
- Active Tuberculosis
- Pulmonary Tuberculosis
- Tuberculosis Meningitis
Also known as: Active Tb, Acute Tuberculosis, Meningeal Tuberculosis, Pulmonary Tb, Tuberculous Meningitis.
Dosing
No dosing information is available for this tab.
Pyrazinamide is administered orally. The fixed-combination preparation containing isoniazid, rifampin, and pyrazinamide (Rifater(R)) should be given either 1 hour before or 2 hours after a meal with a full glass of water.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
No enhanced messaging available.
No enhanced messaging available.
Animal reproduction studies have not been performed with pyrazinamide, and it is also not known whether the drug can cause fetal harm when administered to pregnant women or whether it can affect reproduction capacity. Pyrazinamide should be used during pregnancy only when clearly needed. The American Thoracic Society (ATS), US Centers for Disease Control and Prevention (CDC), and Infectious Diseases Society of America (IDSA) state that routine use of pyrazinamide in pregnant women is not recommended. However, the benefits of pyrazinamide may outweigh the possible (but unquantified) risk in some pregnant women with tuberculosis, especially when resistance to other drugs but susceptibility to pyrazinamide is likely.
Because pyrazinamide is distributed into milk in small amounts, a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the woman.
No enhanced messaging available.
ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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