Ciclodan (ciclopirox olamine)
Topical Antifungals Topical Combination Package (GRAM); Topical Cream (GRAM); Topical Solution, Non-Oral
Last reviewed · Source: First Databank (FDB) drug data
Overview
Ciclopirox and ciclopirox olamine are synthetic antifungal agents.
Ciclopirox olamine cream or lotion is used topically for the treatment of certain dermatophytoses (i.e., tinea pedis, tinea cruris, tinea corporis) caused by Trichophyton mentagrophytes, T. rubrum, Epidermophyton floccosum, or Microsporum canis; for the treatment of tinea (pityriasis) versicolor caused by Malassezia furfur (Pityrosporum orbiculare or P. ovale); and for the treatment of cutaneous candidiasis (moniliasis) caused by Candida albicans. Ciclopirox gel is used topically for the treatment of tinea corporis and interdigital tinea pedis caused by T. rubrum, T. mentagrophytes, or E. floccosum and for the treatment of seborrheic dermatitis of the scalp. Ciclopirox shampoo is used topically for the treatment of seborrheic dermatitis of the scalp.
Ciclopirox solution (nail lacquer) is used topically for the treatment of mild to moderate onychomycosis of fingernails and toenails, without lunula involvement, caused by T. rubrum in immunocompetent patients.
Generic name: ciclopirox olamine
Pronunciation: (SYE-kloe-PIR-ox)
Drug class: Topical Antifungals
Therapeutic class: Dermatological
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Ciclodan
Indications
The following indications are listed for Ciclodan:
- Cutaneous Candidiasis
- Tinea Corporis
- Tinea Cruris
- Tinea Pedis
- Tinea Versicolor
Also known as: Corporeal Ringworm, Cutaneous Candidosis, Cutaneous Moniliasis, Dermatomycosis Pedis, Dhobie Itch, Eczema Marginatum, Jock Itch, Pityriasis Versicolor, Tinea Circinata, Tinea Furfuracea, Tinea Glabrosa, Tinea Inguinalis, Tinea Of The Foot.
Dosing
The labeled strengths of ciclopirox olamine creams and lotions are no longer expressed in terms of the olamine salt (i.e., 1% ciclopirox olamine), but instead are expressed in terms of the base, ciclopirox (i.e., 0.77% ciclopirox).
Ciclopirox olamine is applied topically to the skin as a cream or lotion while ciclopirox is applied topically to the skin as a gel or shampoo and to nails as a solution (nail lacquer). The ciclopirox olamine lotion, which should be shaken vigorously before each use, may be particularly useful for infections involving relatively large areas or areas where a less viscous formulation might be preferred. Occlusive dressings or wrappings should not be used. Ciclopirox and ciclopirox olamine preparations should not be applied to the eye nor administered orally or intravaginally.
Patients should remove any loose nail or nail material (using nail clippers or nail files) before initiating therapy with ciclopirox solution (nail lacquer). Removal of unattached, infected nail(s) as frequently as once monthly by a qualified clinician in nail disorders, weekly self-trimming of infected nail(s) by the patient, and daily application of the topical solution (nail lacquer) are all essential components of the topical management of onychomycosis.
| Drug label | Dosing type | Instructions |
|---|---|---|
| Ciclodan 8% Solution | Maintenance | Apply to the affected area(s) by topical route once daily preferably at bedtime or 8 hours before washing. |
| Ciclodan 0.77% Cream | Maintenance | Apply to the affected and surrounding areas of skin by topical route 2 times per day in the morning and evening. |
| Drug label | Dosing type | Instructions |
|---|---|---|
| Ciclopirox 0.77% Cream | Maintenance | Apply to the affected and surrounding areas of skin by topical route 2 times per day in the morning and evening. |
| Ciclopirox 8% Solution | Maintenance | Apply to the affected area(s) by topical route once daily preferably at bedtime or 8 hours before washing. |
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
- Aspirin exacerbated respiratory disease
- Hemolytic anemia from pyruvate kinase and g6PD deficiencies
- Burns
- No disease contraindications
- Peripheral vascular disease
Adverse reactions
There is no enhanced messaging for this drug.
Rare or Very Rare
- Burns
- Pruritus of skin
- Skin inflammation
- Skin irritation
More Frequent
- Pruritus of skin
- Skin irritation
- Stinging of skin
Less Frequent
- Stinging of skin
Rare or Very Rare
- Erythema
- Hair discoloration
- Nail disorders
Precautions
No enhanced messaging available.
No enhanced messaging available.
Reproduction studies in mice, rats, rabbits, and monkeys using ciclopirox olamine dosages (via various routes of administration) 10 or more times the topical human dosage have not revealed evidence of harm to the fetus. Reproduction studies in rats and rabbits using topical dosages of ciclopirox up to 120 and 100 mg/kg of body weight, respectively, (approximately 121 and 147 times the maximum recommended topical human dosage based on surface area, respectively), also have not revealed evidence of fetotoxicity. In addition, reproduction studies in mice, rats, rabbits, and monkeys using oral dosages of ciclopirox up to 100, 30, 30, and 50 mg/kg of body weight, respectively (approximately 37.5, 30, 44, and 77 times the maximum recommended topical human dosage based on surface area, respectively), have not revealed evidence of fetotoxicity. There are no adequate and controlled studies to date using topical ciclopirox or ciclopirox olamine in pregnant women; topical ciclopirox olamine cream and lotion and ciclopirox shampoo should be used during pregnancy only when clearly needed, while topical ciclopirox gel and solution (nail lacquer) should be used during pregnancy only when the potential benefits justify the possible risks to the fetus.
It is not known whether ciclopirox or ciclopirox olamine is distributed in human milk. Because many drugs are distributed in human milk, ciclopirox or ciclopirox olamine preparations should be used with caution in nursing women.
No enhanced messaging available.
ICD codes
| Code | Type | Description |
|---|---|---|
| Cutaneous candidiasis | ||
| B37.2 | ICD10CM | Candidiasis of skin and nail |
| Onychomycosis due to dermatophyte | ||
| B35.1 | ICD10CM | Tinea unguium |
| Tinea corporis | ||
| B35.4 | ICD10CM | Tinea corporis |
| Tinea cruris | ||
| B35.6 | ICD10CM | Tinea cruris |
| Tinea pedis | ||
| B35.3 | ICD10CM | Tinea pedis |
| Tinea versicolor | ||
| B36.0 | ICD10CM | Pityriasis versicolor |
ICD code information from First Databank (FDB).
Formulary status
Search health-plan coverage for this drug by ZIP code.
Choose the first character of a health plan name.
Last reviewed · Source: First Databank (FDB) drug data
On this page
Actions
Sign in to save favorites
Saving this drug requires a free Physicians Office Resource account.