Drysol (aluminum chloride)
Topical Solution, Non-Oral
Last reviewed · Source: First Databank (FDB) drug data
Overview
Aluminum chloride hexahydrate is an antiperspirant.
The pathophysiology of focal hyperhidrosis is poorly understood. Eccrine (sweat) glands are distributed over nearly the entire body surface with high concentrations in the palms, soles, and forehead. These glands are innervated by cholinergic fibers of the sympathetic nervous system.
Since patients with focal hyperhidrosis do not have any histopathologic changes in sweat glands or increased numbers of sweat glands, it has been suggested that a complex dysfunction of the autonomic nervous system is likely to contribute to hyperhidrosis.
Aluminum chloride hexahydrate mechanically blocks eccrine sweat gland ducts, possibly by forming aluminum ion precipitate complexes within the acrosyringium (most superficial) portion of eccrine glands. Long-term (at least 6 months) use of the drug appears to cause dilation and atrophy of secretory cells within the eccrine sweat glands. The drug does not appear to affect apocrine glands.
USES: This medication is used to help control excessive sweating.
Generic name: aluminum chloride
Pronunciation: (a-LOO-mi-num KLOR-ide)
Therapeutic class: Dermatological
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Drysol
Indications
The following indications are listed for Drysol:
- Hyperhidrosis
Also known as: Diaphoresis, Hyperephidrosis, Hyperidroses, Polyhidrosis, Polyidrosis, Sudorrhea.
Dosing
No dosing information is available for this tab.
When aluminum chloride antiperspirant is used for self-medication, the drug (Certain Dri(R)) should be applied to the underarms only. (For further information on warnings and precautions associated with administration of aluminum chloride hexahydrate (Drysol(R), Xerac(R) AC, and Hypercare(R)), see Topical Administration under Dosage and Administration: Administration.)
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
Aluminum chloride hexahydrate is contraindicated in patients with known hypersensitivity to aluminum chloride hexahydrate or to any ingredient in the formulation.
There are no contraindication contraindications for this drug.
- Acute eruptions of skin
There are no moderate contraindications for this drug.
Adverse reactions
Local skin irritation (burning, stinging, itching, tingling).
There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
No enhanced messaging available.
Aluminum chloride hexahydrate preparations should be kept out of reach of children.
Infants (especially preterm infants) and children may be at greater risk of aluminum exposure from aluminum-containing products because of immature renal function.
The manufacturer of Drysol(R) and Xerac(R) AC states that there is no pregnancy category for these drugs and recommends that these drugs not be used in pregnant women.
No enhanced messaging available.
No enhanced messaging available.
ICD codes
| Code | Type | Description |
|---|---|---|
| Hyperhidrosis | ||
| R61 | ICD10CM | Generalized hyperhidrosis |
ICD code information from First Databank (FDB).
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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