Primatene Asthma (guaifenesin/ephedrine HCl)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Ephedrine is a sympathomimetic agent that occurs naturally in plants of the genus Ephedra; ephedrine stimulates both alpha- and beta-adrenergic receptors.
Guaifenesin is an expectorant.
Generic name: guaifenesin/ephedrine HCl
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Primatene Asthma
Indications
The following indications are listed for Primatene Asthma:
- Cold Symptoms
- Cough
- Nasal Congestion
- Rhinitis
- Rhinorrhea
Also known as: Nasal Stuffiness.
Dosing
Ephedrine is commercially available as ephedrine hydrochloride or ephedrine sulfate; dosage is expressed in terms of the salt.
Guaifenesin is administered orally.
Mucinex(R) 600-mg extended-release tablets should not be broken, crushed, or chewed and should not be used in children younger than 12 years of age; the tablets should be kept out of reach of young children to avoid accidental swallowing and choking.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
No enhanced messaging available.
No enhanced messaging available.
Animal reproduction studies have not been performed to date with ephedrine sulfate injection; it is not known whether the drug can cause fetal harm or miscarriage when administered during pregnancy. However, ephedrine has been used in pregnant women for the treatment of hypotension during spinal anesthesia, and the available data support the efficacy and safety of ephedrine sulfate injection for such use. There is some evidence indicating that fetal acidosis is more likely to occur with maternal administration of ephedrine compared with phenylephrine. Low umbilical artery pH (7.2 or less) has been reported at the time of delivery in neonates whose mothers were exposed to ephedrine. Newborn infants with such maternal exposure should be assessed for their acid-base status and monitored for signs and symptoms of metabolic acidosis.
Limited data indicate that ephedrine is distributed into human milk; however, there is no information regarding the effects of the drug on the breast-fed infant or on milk production. The known benefits of breast-feeding should be considered along with the mother's clinical need for ephedrine and any potential adverse effects of the drug or underlying maternal condition on the infant.
No enhanced messaging available.
ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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