Prepidil (dinoprostone)
Abortifacients Vaginal Gel With Prefilled Applicator (Gram)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Dinoprostone, the naturally occurring prostaglandin E2, stimulates uterine smooth muscle and also produces cervical dilation and softening.
Dinoprostone suppositories are used intravaginally to induce abortion during the second trimester of pregnancy (beyond the 12th week of gestation). Continuous IV infusion of a dilute solution of oxytocin usually is used in conjunction with dinoprostone administration to shorten the induction-to-abortion time and reduce the number of dinoprostone doses required and the number of adverse effects. The mean induction-to-abortion time following intravaginal administration of dinoprostone with IV infusion of oxytocin in second trimester pregnancies is 12-14 hours; abortion occurs in about 90% of patients within 30 hours after the initial dose of dinoprostone.
Generic name: dinoprostone
Pronunciation: (DYE-noe-PROS-tone)
Drug class: Abortifacients
Therapeutic class: Endocrine
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Prepidil
Indications
The following indications are listed for Prepidil:
- Cervical Ripening Procedure
- Induction Of Labor
Dosing
No dosing information is available for this tab.
No dosing information is available for this tab.
| Drug label | Dosing type | Instructions |
|---|---|---|
| Prepidil 0.5 Mg/3 Gm Gel | Maintenance | Insert 1 applicatorful (0.5 mg) by cervical route once, repeat dose in 6 hours as needed; do not exceed 7.5 mL (1.5 mg) in 24hrs. |
No dosing information is available for this tab.
Drug interactions
IV infusion of 500 mL of 10% alcohol injection over a period of 1 hour has been reported to inhibit uterine activity that had been initiated and maintained by IV dinoprostone.
Since dinoprostone may increase activity of oxytocic agents, concomitant use of dinoprostone and oxytocics is not recommended. At least 30 minutes should elapse between removal of dinoprostone vaginal insert and initiation of oxytocin therapy, while an interval of 6-12 hours is recommended for the sequential administration of oxytocin after the use of dinoprostone cervical gel.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
- Abnormal uterine bleeding
- Cephalopelvic disproportion
- Fetal distress
- Genital herpes simplex
- Grand multiparity
- Placenta previa
- Previous cesarean section
- Uterine scar present
- Disseminated intravascular coagulation
- Pulmonary disease
- Uterine hypertonic patterns
- Amniotic membrane rupture
- Anemia
- Asthma
- Cervicitis
- Diabetes mellitus
- Glaucoma
- Hypertension
- Hypotension
- Multiple pregnancy
- Ocular hypertension
- Seizure disorder
- Stenosis of cervix
- Uterine leiomyoma
Adverse reactions
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More Frequent
- Uterine hypertonic patterns
Rare or Very Rare
- Amniotic fluid embolism in childbirth
- Anaphylaxis
- Angioedema
- Bradycardia
- Bronchospastic pulmonary disease
- Chest pain
- Chest tightness
- Contact dermatitis
- Disseminated intravascular coagulation
- Dyspnea
- Hypertension
- Hypotension
- Ocular hypertension
- Peripheral vasoconstriction
- Postpartum hemorrhage
- Pruritus of skin
- Skin rash
- Tachycardia
- Urticaria
- Uterine rupture in pregnancy
- Wheezing
More Frequent
- Abdominal pain with cramps
- Diarrhea
- Fever
- Nausea
- Vomiting
Less Frequent
- Chills
- Headache disorder
Rare or Very Rare
- Back pain
- Dizziness
- Flushing
- Hiccups
- Paralytic ileus
- Vulvar edema
Precautions
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
ICD codes
| Code | Type | Description |
|---|---|---|
| Induction of labor | ||
| O75.5 | ICD10CM | Delayed delivery after artificial rupture of membranes |
ICD code information from First Databank (FDB).
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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