Mitomycin-Sterile Water (mitomycin)
Intravesical Syringe (Ml)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Mitomycin is an antineoplastic antibiotic produced by Streptomyces caespitosus.
Generic name: mitomycin
Therapeutic class: Antineoplastics
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Mitomycin-Sterile Water
Indications
No indications are available for this drug.
Dosing
Dosage of mitomycin must be based on the clinical and hematologic response and tolerance of the patient and whether other myelosuppressive therapy is also being used to obtain optimum therapeutic results with minimum adverse effects. Clinicians should consult published protocols for the dosage of mitomycin and other chemotherapeutic agents and the method and sequence of administration.
No dosing information is available for this tab.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
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There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
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- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- Lactation
- Rupture of bladder
- Increased risk of bleeding due to coagulation disorder
- Pregnancy
- Chronic kidney disease stage 3A (moderate) GFR 45-59 ml/min
- Chronic kidney disease stage 3B (moderate) GFR 30-44 ml/min
Adverse reactions
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Rare or Very Rare
- Urethral stricture
- Urinary retention
More Frequent
- Abnormal hepatic function tests
- Anemia
- Dysuria
- Eosinophilia
- Hematuria
- Hyperkalemia
- Kidney disease with reduction in glomerular filtration rate (GFr)
- Lymphopenia
- Neutropenic disorder
- Urinary tract infection
Less Frequent
- Balanitis
- Edema of male genital organs
- Fatigue
- Genital organ pruritus
- Increased urinary frequency
- Pain in penis
- Swelling of vagina
- Urethritis
- Urinary incontinence
- Urinary urgency
- Vulvovaginal pain
Precautions
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Mitomycin has produced teratogenic effects in animals. Safe use of mitomycin in pregnant women has not been established.
It is not known whether mitomycin is distributed in milk. Because of the potential for serious adverse reactions to mitomycin in nursing infants, nursing should be discontinued during mitomycin therapy.
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ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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