Miconatate (miconazole nitrate/tolnaftate)

No dosing information is available for this tab.

Miconazole nitrate is administered topically as a cream, powder, or aerosol powder or tincture, or intravaginally as a vaginal cream or suppository. Miconazole powder or aerosol powder are not recommended for use on the scalp or nails.

Tolnaftate is applied topically to infected skin as a 1% cream, aerosol liquid spray, aerosol powder spray, powder, or solution.

Contact with eyes, nose, mouth, and other mucous membranes should be avoided. Tolnaftate should not be used on nail or scalp infections.

Prior to application, the infected area should be cleaned with soap and water and dried thoroughly.

The powder or aerosol powder is used alone for the treatment of mild infections or as an adjunct to the cream or solution or systemic antifungal agents when drying of the lesion is desired.

A small amount of the cream or powder or 2 or 3 drops of the solution should be rubbed gently into affected areas. If the aerosol liquid spray or aerosol spray powder is used, a thin layer should be applied.

When used for the treatment of tinea pedis, special attention should be paid to applying the drug in the spaces between the toes. In addition, patients with tinea pedis should wear well-fitting, ventilated shoes and change their shoes and socks at least once daily.

No dosing information is available for this tab.

No dosing information is available for this tab.

There is no enhanced messaging for this drug.

There are no contraindication interactions for this drug.

There are no severe interactions for this drug.

There are no moderate interactions for this drug.

There is no enhanced messaging for this drug.

There are no contraindication contraindications for this drug.

There are no severe contraindications for this drug.

• No disease contraindications

There is no enhanced messaging for this drug.

Rare or Very Rare

• Anaphylaxis
• Angioedema
• Blistering skin
• Skin rash

More Frequent

• Pruritus of skin
• Skin inflammation
• Skin irritation

Rare or Very Rare

• Abnormal hair texture
• Alopecia
• Cheilitis
• Dermatitis due to topical drug
• Dermatitis due to topical drug
• Dry skin
• Erythema
• Erythema
• Hair discoloration
• Paresthesia
• Skin irritation
• Skin rash
• Stinging of skin

No enhanced messaging available.

No enhanced messaging available.

Because small amounts of miconazole nitrate are absorbed from the vagina, the manufacturer states that the vaginal preparations should not be used in the first trimester of pregnancy unless the drug is considered essential to the welfare of the patient. For self-medication, miconazole nitrate vaginal suppositories or vaginal cream should not be used in pregnant women unless otherwise instructed by a physician. Follow-up reports from clinical studies during which miconazole vaginal preparations were used for up to 14 days in pregnant women have revealed no adverse effects or complications attributable to therapy with the drug in infants born to these women. Prolonged gestation has occurred in rats, but not in rabbits, receiving oral miconazole nitrate. In addition, fetotoxicity and embryotoxicity have occurred in rats and rabbits and dystocia in rats in reproduction studies using oral miconazole nitrate dosages of 80 mg/kg and higher; these effects were not observed in rats following intravaginal administration of the drug.

There are no adequate and controlled studies to date using tolnaftate in pregnant women, and the drug should be used during pregnancy only when clearly needed.

It is not known whether miconazole nitrate is distributed into milk. Miconazole nitrate should be used with caution in nursing women.

It is not known whether tolnaftate is distributed into milk. Safe use of tolnaftate in nursing women has not been established.

No enhanced messaging available.