Thiola Ec (tiopronin)
Urinary Stone Agents Oral Tablet, Delayed Release (Enteric Coated)
Last reviewed · Source: First Databank (FDB) drug data
Overview
USES: This medication is used to prevent kidney stones in people with a certain inherited disorder (cystinuria). Cystinuria occurs when there is too much of a certain natural substance (the amino acid cystine) in the urine, leading to formation of kidney stones. Tiopronin works by making cystine more dissolvable in the urine.
This medication should be used in combination with other methods to prevent kidney stones (such as drinking plenty of water, taking alkali treatment, following a special diet).
Generic name: tiopronin
Pronunciation: (tye-OH-proe-nin)
Drug class: Urinary Stone Agents
Therapeutic class: Genitourinary Therapy
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Thiola Ec
Indications
The following indications are listed for Thiola Ec:
- Cystinuria
Dosing
No dosing information is available for this tab.
No dosing information is available for this tab.
| Drug label | Dosing type | Instructions |
|---|---|---|
| Thiola Ec 300 Mg Tablet | Maintenance | Take 1 tablet (300 mg) by oral route 3 times per day at the same times each day. |
| Thiola Ec 100 Mg Tablet | Maintenance | Take 3 tablets (300 mg) by oral route 3 times per day at the same times each day. |
| Drug label | Dosing type | Instructions |
|---|---|---|
| Tiopronin Dr 100 Mg Tablet | Maintenance | Take 3 tablets (300 mg) by oral route 3 times per day at the same times each day. |
| Tiopronin Dr 300 Mg Tablet | Maintenance | Take 1 tablet (300 mg) by oral route 3 times per day at the same times each day. |
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
Moderate Interaction: Assess the risk to the patient and take action as needed.
Tiopronin (Enteric-Coated)/Alcohol
SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed.
MECHANISM OF ACTION: Alcohol may result in a faster release of delayed-release tiopronin.(1)
CLINICAL EFFECTS: Concurrent use of alcohol in patients taking delayed-release tiopronin may increase the risk of side effects.(1)
PREDISPOSING FACTORS: None determined.
PATIENT MANAGEMENT: Counsel patients to avoid alcohol 2 hours before and 3 hours after taking delayed-release tiopronin.(1) Significant quantities of alcohol may be present in medicinal products. Alcohol is is used to improve docetaxel and paclitaxel solubility. - The quantity of alcohol in paclitaxel injection formulations (0.385-0.396 grams/mL) is similar across manufacturers. A paclitaxel 200 mg dose contains approximately 13 grams of alcohol. - The quantity of alcohol in docetaxel formulations varies approximately 3-fold depending upon the manufacturer. FDA data on alcohol content (3): Product Manufacturer Alcohol/200 mg dose Docetaxel Inj. Pfizer 6.4 grams Docetaxel Inj. Sandoz 5.5 grams Docetaxel Inj. Accord 4.0 grams Taxotere-one vial Sanofi 4.0 grams formulation Docetaxel Inj. Hospira 3.7 grams Docefrez Sun Pharma 2.9 grams Taxotere-two vial Sanofi 2.0 grams formulation
DISCUSSION: An in vitro study found that alcohol (5, 10, 20, and 40 %) increased the dissolution rate of delayed-release tiopronin tablets.(1)
Contraindications
There is no enhanced messaging for this drug.
- Lactation
- Proteinuria
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
More Frequent
- Allergic dermatitis
- Aphthous stomatitis
- Ecchymosis
- Elastosis perforans serpiginosa
- Jaundice
- Pemphigus
- Pruritus of skin
- Urticaria
Less Frequent
- Anemia
- Arthralgia
- Blood dyscrasias
- Chills
- Dyspnea
- Edema
- Eosinophilia
- Fever
- Hematuria
- Laryngeal edema
- Leukopenia
- Lymphadenopathy
- Myalgia
- Nephrotic syndrome
- Proteinuria
- Thrombocytopenic disorder
Rare or Very Rare
- Angioedema
- Bronchiolitis
- Chronic heart failure
- Goodpasture's syndrome
- Hemoptysis
- Pharyngitis
- Pulmonary infiltrates
- Renal failure
- Systemic lupus erythematosus
More Frequent
- Abnormal desquamation
- Anorexia
- Diarrhea
- Dry skin
- Fatigue
- Flatulence
- Nausea
- Skin atrophy
- Skin rash
- Vomiting
Less Frequent
- Dysgeusia
- General weakness
- Parosmia
Rare or Very Rare
- Abdominal distension
- Acute abdominal pain
- Cheilosis
- Chest pain
- Dyspepsia
- Headache disorder
- Hypoesthesia
- Loss of taste
- Neck pain
- Peripheral edema
- Vertigo
- Weight gain
- Xerostomia
Precautions
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
ICD codes
| Code | Type | Description |
|---|---|---|
| Cystinuria | ||
| E72.01 | ICD10CM | Cystinuria |
ICD code information from First Databank (FDB).
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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