Upneeq (oxymetazoline HCl/PF)
Ophthalmic Adrenergic Agents Ophthalmic (EYE) Dropperette, Single-Use Drop Dispenser
Last reviewed · Source: First Databank (FDB) drug data
Overview
Oxymetazoline hydrochloride, an imidazoline-derivative sympathomimetic amine, is a vasoconstrictor.
USES: This medication is used to treat a certain eyelid condition (acquired blepharoptosis) that causes drooping upper eyelid(s). It belongs to a class of drugs known as alpha agonists. Oxymetazoline works by making a certain eyelid muscle get shorter and tighter (contract).
Generic name: oxymetazoline HCl/PF
Pronunciation: (OX-i-me-TAZ-oh-leen)
Drug class: Ophthalmic Adrenergic Agents
Therapeutic class: Ophthalmic Agents
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Upneeq
Indications
The following indications are listed for Upneeq:
- Acquired Blepharoptosis
Also known as: Acquired Ptosis Of Eyelid.
Dosing
No dosing information is available for this tab.
Oxymetazoline hydrochloride nasal solutions are applied topically to the nasal mucosa as sprays. Oxymetazoline hydrochloride nasal solutions also are administered by a nasal pump that produces metered sprays. Ophthalmic solutions of the drug are applied topically to the conjunctiva. Care must be taken to avoid contamination of the dropper, inhaler, or spray dispenser. It is recommended that contact lenses be removed before topical administration of the ophthalmic solution.
Sprays (including metered sprays) should be delivered or pumped into each nostril with the patient's head erect so that excess solution is not released. Prior to initial use of metered sprays, the nasal inhalers should be primed by depressing the pump firmly several times. To minimize the risk of spreading infections, droppers, inhalers, and spray dispensers should not be used by more than one person, and tips of the dispensers, inhalers, or droppers should be rinsed with hot water or wiped clean following use.
| Drug label | Dosing type | Instructions |
|---|---|---|
| Upneeq 0.1% Eye Drop | Maintenance | Instill 1 drop into affected eye(s) by ophthalmic route once daily. |
No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
There are no contraindication contraindications for this drug.
- Angle-closure glaucoma
- Ocular infection
- Coronary artery disease
- Hypertension
- Hyperthyroidism
- Sjogren's syndrome
Adverse reactions
There is no enhanced messaging for this drug.
Rare or Very Rare
- Cardiac arrhythmia
- Tachycardia
- Tremor
More Frequent
- Blurred vision
- Dry eye
- Punctate keratitis
Less Frequent
- Ocular irritation
Rare or Very Rare
- Conjunctival hyperemia
- Dizziness
- Headache disorder
- Insomnia
- Nervousness
Precautions
No enhanced messaging available.
No enhanced messaging available.
Safe use of oxymetazoline during pregnancy has not been established. Oxymetazoline hydrochloride ophthalmic or nasal solutions should be used during pregnancy only when instructed by a clinician.
It is not known whether oxymetazoline is distributed into milk. Topical oxymetazoline preparations should be used with caution in nursing women.
No enhanced messaging available.
ICD codes
| Code | Type | Description |
|---|---|---|
| Acquired blepharoptosis | ||
| H02.4 | ICD10CM | Ptosis of eyelid |
| H02.40 | ICD10CM | Unspecified ptosis of eyelid |
| H02.401 | ICD10CM | Unspecified ptosis of right eyelid |
| H02.402 | ICD10CM | Unspecified ptosis of left eyelid |
| H02.403 | ICD10CM | Unspecified ptosis of bilateral eyelids |
| H02.409 | ICD10CM | Unspecified ptosis of unspecified eyelid |
| H02.41 | ICD10CM | Mechanical ptosis of eyelid |
| H02.411 | ICD10CM | Mechanical ptosis of right eyelid |
| H02.412 | ICD10CM | Mechanical ptosis of left eyelid |
| H02.413 | ICD10CM | Mechanical ptosis of bilateral eyelids |
| H02.419 | ICD10CM | Mechanical ptosis of unspecified eyelid |
| H02.42 | ICD10CM | Myogenic ptosis of eyelid |
| H02.421 | ICD10CM | Myogenic ptosis of right eyelid |
| H02.422 | ICD10CM | Myogenic ptosis of left eyelid |
| H02.423 | ICD10CM | Myogenic ptosis of bilateral eyelids |
| H02.429 | ICD10CM | Myogenic ptosis of unspecified eyelid |
| H02.43 | ICD10CM | Paralytic ptosis of eyelid |
| H02.431 | ICD10CM | Paralytic ptosis of right eyelid |
| H02.432 | ICD10CM | Paralytic ptosis of left eyelid |
| H02.433 | ICD10CM | Paralytic ptosis of bilateral eyelids |
| H02.439 | ICD10CM | Paralytic ptosis unspecified eyelid |
ICD code information from First Databank (FDB).
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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