Tobramycin-Dexamethasone (tobramycin/dexamethasone)
Ophthalmic Antibacterials Ophthalmic (EYE) Suspension, Drops(FINAL DOSAGE FORM)(ML)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Tobramycin is an aminoglycoside antibiotic.
Dexamethasone is a synthetic fluorinated corticosteroid.
USES: This medication is used to treat or prevent eye infections. This medication contains two drugs. Tobramycin belongs to a class of drugs called aminoglycoside antibiotics.
It works by stopping the growth of bacteria. Dexamethasone belongs to a class of drugs called corticosteroids. It works by reducing swelling.
This medication treats/prevents only bacterial eye infections. It will not work for other types of eye infections. Using any antibiotic when it is not needed can cause it to not work for future infections.
Generic name: tobramycin/dexamethasone
Pronunciation: (TOE-bra-MYE-sin/dex-uh-METH-uh-sown)
Drug class: Ophthalmic Antibacterials
Therapeutic class: Ophthalmic Agents
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Tobramycin-Dexamethasone
Indications
The following indications are listed for Tobramycin-Dexamethasone:
- Ocular Inflammation
- Superficial Ocular Infection
Also known as: Ophthalmic Inflammation, Superficial Ophthalmic Infection.
Dosing
Dexamethasone or its sodium phosphate salt is applied topically to the eye or the ear. Potency of the sodium phosphate preparations is expressed in terms of dexamethasone phosphate. Care should be taken to avoid contamination of the tip of the ointment tube or dropper when the drug is used ophthalmically.
No dosing information is available for this tab.
| Drug label | Dosing type | Instructions |
|---|---|---|
| Tobramycin-Dexameth Ophth Susp | Maintenance | Instill 1 drop into affected eye(s) by ophthalmic route every 6 hours. |
| Drug label | Dosing type | Instructions |
|---|---|---|
| Tobramycin-Dexameth Ophth Susp | Maintenance | Instill 1 drop into affected eye(s) by ophthalmic route every 6 hours. |
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
- Fungal infection of eye
- Herpes simplex dendritic keratitis
- Tuberculosis of the eye
- Vaccinia virus keratitis
- Amebic infection of the eye
- Ocular hypertension
- Corneal erosion
- Diabetes mellitus
- Krukenberg spindle
- No disease contraindications
- Open angle glaucoma
- Severe myopia
Adverse reactions
There is no enhanced messaging for this drug.
Less Frequent
- Ocular hypertension
- Ocular inflammation
- Ocular itching
- Ocular redness
Rare or Very Rare
- Adrenocortical insufficiency
- Anaphylaxis
- Cataracts
- Central serous chorioretinopathy
- Corneal degeneration
- Corneal edema
- Corneal erosion
- Corneal ulcer
- Erythema multiforme
- Fungal infection of eye
- Glaucoma
- Globe perforation
- Hypercortisolism
- Hypersensitivity drug reaction
- Hypersensitivity drug reaction
- Keratitis
- Optic nerve damage
- Punctate keratitis
- Punctate keratitis
- Reduced visual acuity
- Stevens-johnson syndrome
- Uveitis
- Visual changes
- Visual field defect
More Frequent
- Blurred vision
Less Frequent
- Blurred vision
- Conjunctival hyperemia
- Headache disorder
- Iritis
- Ocular irritation
- Ocular pain
- Ocular pain
Rare or Very Rare
- Accommodation disorder
- Allergic dermatitis
- Blepharoptosis
- Calcification of cornea
- Chemosis
- Conjunctival hyperemia
- Conjunctivitis
- Dizziness
- Dysgeusia
- Eye tearing
- Eyelid edema
- Foreign body sensation of eye
- Impaired wound healing
- Mydriasis
- Ocular infection
- Ocular irritation
- Ocular itching
- Ocular redness
- Photophobia
- Urticaria
Precautions
No enhanced messaging available.
No enhanced messaging available.
Animal reproduction studies using systemic tobramycin dosages up to 33 times the usual human systemic dosage have not revealed evidence of impaired fertility or harm to the fetus.
There are no controlled studies to date using tobramycin ophthalmic preparations in pregnant women.
Tobramycin ophthalmic ointment and ophthalmic solution should be used during pregnancy only if clearly needed.
Fixed-combination ophthalmic preparations containing tobramycin and a corticosteroid (i.e., dexamethasone or loteprednol etabonate) should be used during pregnancy only if potential benefits justify potential risks to the fetus.
A decision should be made whether to discontinue nursing or discontinue tobramycin ophthalmic preparations, taking into account the importance of the drug to the woman.
The manufacturers state that caution is advised if fixed-combination ophthalmic preparations containing tobramycin and a corticosteroid are used in nursing women.
No enhanced messaging available.
ICD codes
| Code | Type | Description |
|---|---|---|
| Ocular inflammation | ||
| H57.8 | ICD10CM | Other specified disorders of eye and adnexa |
| T86.840 | ICD10CM | Corneal transplant rejection |
| T86.8401 | ICD10CM | Corneal transplant rejection, right eye |
| T86.8402 | ICD10CM | Corneal transplant rejection, left eye |
| T86.8403 | ICD10CM | Corneal transplant rejection, bilateral |
| T86.8409 | ICD10CM | Corneal transplant rejection, unspecified eye |
| T86.841 | ICD10CM | Corneal transplant failure |
| T86.8411 | ICD10CM | Corneal transplant failure, right eye |
| T86.8412 | ICD10CM | Corneal transplant failure, left eye |
| T86.8413 | ICD10CM | Corneal transplant failure, bilateral |
| T86.8419 | ICD10CM | Corneal transplant failure, unspecified eye |
| T86.842 | ICD10CM | Corneal transplant infection |
| T86.8421 | ICD10CM | Corneal transplant infection, right eye |
| T86.8422 | ICD10CM | Corneal transplant infection, left eye |
| T86.8423 | ICD10CM | Corneal transplant infection, bilateral |
| T86.8429 | ICD10CM | Corneal transplant infection, unspecified eye |
| Superficial ocular infection | ||
| H10.0 | ICD10CM | Mucopurulent conjunctivitis |
| H10.01 | ICD10CM | Acute follicular conjunctivitis |
| H10.011 | ICD10CM | Acute follicular conjunctivitis, right eye |
| H10.012 | ICD10CM | Acute follicular conjunctivitis, left eye |
| H10.013 | ICD10CM | Acute follicular conjunctivitis, bilateral |
| H10.019 | ICD10CM | Acute follicular conjunctivitis, unspecified eye |
| H10.02 | ICD10CM | Other mucopurulent conjunctivitis |
| H10.021 | ICD10CM | Other mucopurulent conjunctivitis, right eye |
| H10.022 | ICD10CM | Other mucopurulent conjunctivitis, left eye |
| H10.023 | ICD10CM | Other mucopurulent conjunctivitis, bilateral |
| H10.029 | ICD10CM | Other mucopurulent conjunctivitis, unspecified eye |
ICD code information from First Databank (FDB).
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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