Acioxiay (azelaic acid/niacinamide)
Acne Products Topical Cream (GRAM)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Azelaic acid is a naturally occurring aliphatic dicarboxylic acid that exhibits various dermatologic effects including antibacterial and antiproliferative activity.
Azelaic acid is a naturally occurring aliphatic dicarboxylic acid that exhibits various dermatologic effects including antibacterial and antiproliferative activity.
The exact mechanism of action of topically applied azelaic acid in the treatment of acne vulgaris has not been fully elucidated; however, the effect appears to result partly from the antibacterial activity of the drug. Azelaic acid inhibits the growth of susceptible organisms (principally Propionibacterium acnes) on the surface of the skin by inhibiting protein synthesis. In addition, the drug also may inhibit follicular keratinization, which may prevent development or maintenance of comedones.
Azelaic acid usually is bacteriostatic in action, but may be bactericidal in high concentrations against P. acnes and Staphylococcus epidermidis. Azelaic acid also exhibits antiproliferative effects against hyperactive and abnormal melanocytes but does not exhibit an appreciable depigmenting effect on normally pigmented skin.
The precise mechanism(s) of action of topically applied azelaic acid in the treatment of rosacea is unknown.
The American Society of Health-System Pharmacists, Inc. represents that the information provided in the accompanying monograph was formulated with a reasonable standard of care, and in conformity with professional standards in the field. Readers are advised that decisions regarding use of drugs are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and that the information contained in the monograph is provided for informational purposes only. The manufacturer's labeling should be consulted for more detailed information.
The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information contained in the monograph is not a substitute for medical care.
Generic name: azelaic acid/niacinamide
Drug class: Acne Products
Therapeutic class: Dermatological
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Acioxiay
Indications
No indications are available for this drug.
Dosing
The manufacturer states that safety and efficacy of azelaic acid cream in children younger than 12 years of age have not been established. The manufacturer states that safety and efficacy of azelaic acid gel in pediatric patients have not been established.
Azelaic acid is applied topically to the skin as a 20% cream or 15% gel. Prior to application of the cream or gel, the affected areas should be cleansed and dried. The cream or gel is then applied and massaged gently into the affected areas. Occlusive dressings or wrappings should not be used, and hands should be washed after applying the cream or gel. Cosmetics may be applied to the skin after the gel has dried. The cream or gel should not be applied to the eye. In addition, contact with the mouth, eyes, and other mucous membranes should be avoided. If contact with the eye(s) occurs, the eye(s) should be washed with large amounts of water; patients should consult a clinician if ocular irritation persists.
The manufacturer states that patients receiving azelaic acid gel for the treatment of rosacea should be instructed to avoid spicy foods, thermally hot foods and drinks, and alcoholic beverages and to use only very mild soaps or soapless cleansing lotions for facial cleaning during therapy with the drug.
Skin irritation (e.g., pruritus, burning, stinging) may occur during the initial weeks of therapy with azelaic acid cream or gel; if irritation is excessive or persists, the drug should be discontinued and the clinician should be contacted. Patients with dark complexions should be monitored for early signs of hypopigmentation during azelaic acid therapy.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
- Asthma
- No disease contraindications
Adverse reactions
There is no enhanced messaging for this drug.
Rare or Very Rare
- Angioedema
- Asthma exacerbation
- Dyspnea
- Urticaria
- Wheezing
More Frequent
- Dry skin
- Erythema
- Paresthesia
- Pruritus of skin
- Skin inflammation
- Stinging of skin
Rare or Very Rare
- Abnormal desquamation
- Application site rash
- Facial edema
- Hirsutism
- Ocular irritation
- Periorbital edema
- Recurrent herpes simplex labialis
- Skin hypopigmentation
- Vitiligo
Precautions
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
ICD codes
No ICD codes are available for this drug.
Formulary status
Search health-plan coverage for this drug by ZIP code.
Choose the first character of a health plan name.
Last reviewed · Source: First Databank (FDB) drug data
On this page
Actions
Sign in to save favorites
Saving this drug requires a free Physicians Office Resource account.