Carboprost Tromethamine (carboprost tromethamine)
Abortifacients Intramuscular Vial (ML)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Stimulates uterine smooth muscle; synthetic derivative of prostaglandin F2alpha.
Elicits pharmacologic responses usually produced by endogenous prostaglandin F2alpha; more potent and has longer duration of activity on the uterus than prostaglandin F2alpha.
Increases the amplitude and frequency of uterine contractions throughout pregnancy; uterine response to the drug increases with the duration of pregnancy.
After delivery, uterine contractions impede uterine blood flow.
Produces cervical dilation.
Produces contraction of vascular smooth muscle; may result in increased blood pressure.
Causes stimulation of the smooth muscle of the GI tract, increasing GI motility.
Stimulates transient bronchoconstriction in some patients.
Generic name: carboprost tromethamine
Drug class: Abortifacients
Therapeutic class: Endocrine
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Carboprost Tromethamine
Indications
The following indications are listed for Carboprost Tromethamine:
- Abortion
- Postpartum Hemorrhage
Also known as: Postpartum Bleeding, Termination Of Pregnancy.
Dosing
Available as carboprost tromethamine; dosage is expressed in terms of carboprost.
Closely adhere to recommended dosage. Dosage determined by uterine response.
No dosing information is available for this tab.
| Drug label | Dosing type | Instructions |
|---|---|---|
| Carboprost 250 Mcg/Ml Vial | Maintenance | Inject 250 mcg by intramuscular route initially, the dosage being repeated every 1.5-3.5 hours depending on uterine response. |
| Drug label | Dosing type | Instructions |
|---|---|---|
| Carboprost 250 Mcg/Ml Vial | Maintenance | Inject 250 mcg by intramuscular route initially, the dosage being repeated every 1.5-3.5 hours depending on uterine response. |
Drug interactions
May increase activity of other oxytocic agents; concomitant use not recommended.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
Known hypersensitivity to carboprost.
Acute pelvic inflammatory disease.
Active cardiac, pulmonary, renal, or hepatic disease.
- Inflammatory disease of female pelvic organs
- Pregnancy- third trimester
- Atherosclerotic cardiovascular disease
- Disease of liver
- Kidney disease with reduction in glomerular filtration rate (GFr)
- Pulmonary disease
- Anemia
- Asthma
- Diabetes mellitus
- Hypertension
- Hypotension
- Seizure disorder
- Uterine scar present
Adverse reactions
Vomiting, diarrhea, nausea, fever, flushing.
Rare or Very Rare
- Allergic dermatitis
- Anaphylaxis
- Angioedema
- Bradycardia
- Bronchospastic pulmonary disease
- Chest pain
- Dyspnea
- Hypertension
- Injection site sequelae
- Paralytic ileus
- Peripheral vasoconstriction
- Skin rash
- Tachycardia
- Wheezing
More Frequent
- Cough
- Diarrhea
- Nausea
- Vomiting
Less Frequent
- Abdominal pain with cramps
- Back pain
- Blepharospasm
- Blurred vision
- Chest tightness
- Chills
- Dizziness
- Epistaxis
- Fever
- Flushing
- Headache disorder
- Hiccups
- Hyperhidrosis
- Mastalgia
- Myalgia
- Nervousness
- Paresthesia
- Polydipsia
- Sleep disorder
Precautions
No enhanced messaging available.
Not indicated in pediatric patients.
Large amounts of benzyl alcohol (i.e., 100-400 mg/kg daily) have been associated with toxicity (fatal ''gasping syndrome'') in neonates; each mL of carboprost tromethamine injection contains 9.45 mg of benzyl alcohol.
Category C. (See Users Guide.)
No enhanced messaging available.
No enhanced messaging available.
ICD codes
| Code | Type | Description |
|---|---|---|
| Abortion | ||
| 10A07ZX | ICD10PCS | Abortion of products of conception, abortifacient, via natural or artificial opening |
| Z33.2 | ICD10CM | Encounter for elective termination of pregnancy |
| Postpartum hemorrhage | ||
| O72 | ICD10CM | Postpartum hemorrhage |
| O72.1 | ICD10CM | Other immediate postpartum hemorrhage |
ICD code information from First Databank (FDB).
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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