Mupirocin (mupirocin)
Topical Antibiotics Topical Cream (Gram); Topical Ointment (Gram)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Mupirocin is a pseudomonic acid antibiotic produced by Pseudomonas fluorescens.
USES: Mupirocin is used to treat certain skin infections (such as impetigo). It is an antibiotic. It works by stopping the growth of certain bacteria.
Generic name: mupirocin
Pronunciation: (mue-PIR-oh-sin)
Drug class: Topical Antibiotics
Therapeutic class: Dermatological
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Mupirocin
Indications
The following indications are listed for Mupirocin:
- Impetigo
Also known as: Impetigo Contagiosa, Impetigo Vulgaris.
Dosing
No dosing information is available for this tab.
No dosing information is available for this tab.
| Drug label | Dosing type | Instructions |
|---|---|---|
| Mupirocin 2% Ointment | Maintenance | Apply a small amount to the affected area by topical route 3 times per day. |
| Mupirocin 2% Cream | Maintenance | Apply a small amount to the affected area by topical route 3 times per day for 10 days. |
| Drug label | Dosing type | Instructions |
|---|---|---|
| Mupirocin 2% Ointment | Maintenance | Apply a small amount to the affected area by topical route 3 times per day. |
| Mupirocin 2% Cream | Maintenance | Apply a small amount to the affected area by topical route 3 times per day for 10 days. |
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
- No disease contraindications
Adverse reactions
There is no enhanced messaging for this drug.
Rare or Very Rare
- Anaphylaxis
- Angioedema
- Clostridioides difficile infection
More Frequent
- Headache disorder
- Nausea
- Skin rash
Less Frequent
- Dry skin
- Erythema
- Pruritus of skin
- Skin inflammation
- Skin swelling
- Stinging of skin
- Treatment site sequelae
Rare or Very Rare
- Acute abdominal pain
- Aphthous stomatitis
- Dizziness
- Pain
- Urticaria
Precautions
No enhanced messaging available.
No enhanced messaging available.
Data are insufficient to determine whether there is a drug-associated risk with use of mupirocin ointment for dermatologic use, mupirocin calcium cream for dermatologic use, or mupirocin calcium ointment for intranasal use in pregnant women. One manufacturer states that mupirocin ointment for dermatologic use should be used during pregnancy only if clearly needed.
Systemic absorption of mupirocin following topical application to intact skin is minimal. Although systemic absorption of mupirocin was reported to be negligible following intranasal application of mupirocin calcium ointment for intranasal use in adults, the dosage regimen used in this study did not mimic the recommended intranasal dosage.
Reproduction studies in rats or rabbits using subcutaneous mupirocin in dosages up to 22 or 43 times, respectively, the usual human topical dosage or up to 65 or 130 times, respectively, the usual human intranasal dosage have not revealed evidence of developmental toxicity.
It is not known whether systemically absorbed mupirocin is distributed into human milk, affects milk production, or affects the breast-fed infant. Because systemic absorption of mupirocin is minimal following topical application to skin and negligible following intranasal administration, the manufacturers state that mupirocin exposure in breast-feeding infants is unlikely.
The benefits of breast-feeding and the importance of mupirocin to the woman should be considered along with potential adverse effects on the breast-fed child from the drug or from the underlying maternal condition.
One manufacturer states that mupirocin ointment for dermatologic use should be used with caution in nursing women.
If a breast and/or nipple is being treated with mupirocin ointment for dermatologic use or mupirocin calcium cream for dermatologic use, the treated area should be thoroughly washed prior to breast-feeding to minimize oral exposure to the drug in the breast-feeding infant.
No enhanced messaging available.
ICD codes
| Code | Type | Description |
|---|---|---|
| Impetigo | ||
| L01 | ICD10CM | Impetigo |
| L01.0 | ICD10CM | Impetigo |
| L01.00 | ICD10CM | Impetigo, unspecified |
| L01.03 | ICD10CM | Bullous impetigo |
| L01.09 | ICD10CM | Other impetigo |
| L01.1 | ICD10CM | Impetiginization of other dermatoses |
| Staph aureus traumatic skin lesion infection | ||
| B95.6 | ICD10CM | Staphylococcus aureus as the cause of diseases classified elsewhere |
| B95.61 | ICD10CM | Methicillin susceptible staphylococcus aureus infection as the cause of diseases classified elsewhere |
| B95.62 | ICD10CM | Methicillin resistant staphylococcus aureus infection as the cause of diseases classified elsewhere |
| Traumatic skin lesion streptococcus pyogenes infection | ||
| B95.0 | ICD10CM | Streptococcus, group a, as the cause of diseases classified elsewhere |
ICD code information from First Databank (FDB).
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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