Thiothixene (thiothixene)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Thiothixene is a thioxanthene-derivative antipsychotic agent. The drug is considered a conventional or first-generation antipsychotic agent.
USES: This medication is used to treat certain mental/mood disorders (such as schizophrenia). Thiothixene belongs to a class of drugs known as antipsychotics. It works by helping to restore the balance of certain natural substances in the brain.
Generic name: thiothixene
Pronunciation: (thigh-oh-THICKS-een)
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Thiothixene
Indications
The following indications are listed for Thiothixene:
- Schizophrenia
Also known as: Dementia Praecox, Parergasia.
Dosing
No dosing information is available for this tab.
Thiothixene is administered orally. Thiothixene hydrochloride has been given orally and parenterally, but the hydrochloride form of the drug is no longer commercially available in the US.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
Thiothixene may be additive with or may potentiate the action of other CNS depressants (including alcohol), anticholinergics, or hypotensive agents. The drug does not appear to potentiate the anticonvulsant activity of barbiturates. The dosage of anticonvulsant drugs should therefore not be reduced initially if thiothixene is added to the regimen of an epileptic patient. Patients who are receiving hypotensive agents should be observed closely for signs of excessive hypotension when thiothixene is added to their drug regimen.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
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Although animal reproduction studies and clinical experience to date have not demonstrated any teratogenic effects, safe use of thiothixene during pregnancy has not been established.
Neonates exposed to antipsychotic agents, including thiothixene, during the third trimester of pregnancy are at risk for extrapyramidal and/or withdrawal symptoms following delivery. Symptoms reported in these neonates to date include agitation, hypertonia, hypotonia, tardive dyskinetic-like symptoms, tremor, somnolence, respiratory distress, and feeding disorder. Any neonate exhibiting extrapyramidal or withdrawal symptoms following in utero exposure to antipsychotic agents should be monitored. Symptoms were self-limiting in some neonates, but varied in severity; some infants required intensive care unit support and prolonged hospitalization. For further information on extrapyramidal and withdrawal symptoms in neonates, see Cautions: Pregnancy, Fertility, and Lactation, in the Phenothiazines General Statement 28:16.08.24.
Thiothixene should only be used during pregnancy if the potential benefits to the woman outweigh the possible risks to the woman and fetus.
No enhanced messaging available.
No enhanced messaging available.
ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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