Zylet (tobramycin/loteprednol etabonate)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Tobramycin is an aminoglycoside antibiotic.
Loteprednol etabonate is a synthetic nonfluorinated corticosteroid.
USES: This medication is used to treat conditions involving swelling (inflammation) of the eyes and to treat or prevent bacterial eye infections. This product contains tobramycin, an antibiotic that works by stopping the growth of bacteria. It also contains loteprednol, an anti-inflammatory corticosteroid that works by reducing swelling, redness, and itching.
This medication treats/prevents only bacterial eye infections. It will not work for other types of eye infections. Using any antibiotic when it is not needed can cause it to not work for future infections.
Generic name: tobramycin/loteprednol etabonate
Pronunciation: (TOE-bra-MYE-sin/LOE-te-PRED-nol)
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Zylet
Indications
The following indications are listed for Zylet:
- Ocular Inflammation
- Superficial Ocular Infection
Also known as: Ophthalmic Inflammation, Superficial Ophthalmic Infection.
Dosing
Safety and efficacy of ophthalmic suspensions containing loteprednol etabonate alone or in fixed combination with tobramycin have not been established in children younger than 18 years of age.
Loteprednol etabonate alone or in fixed combination with tobramycin is applied topically to the eye as an ophthalmic suspension. The suspension should be shaken vigorously prior to use. Care should be taken to avoid contamination of the container.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
No enhanced messaging available.
No enhanced messaging available.
Animal reproduction studies using systemic tobramycin dosages up to 33 times the usual human systemic dosage have not revealed evidence of impaired fertility or harm to the fetus.
There are no controlled studies to date using tobramycin ophthalmic preparations in pregnant women.
Tobramycin ophthalmic ointment and ophthalmic solution should be used during pregnancy only if clearly needed.
Fixed-combination ophthalmic preparations containing tobramycin and a corticosteroid (i.e., dexamethasone or loteprednol etabonate) should be used during pregnancy only if potential benefits justify potential risks to the fetus.
A decision should be made whether to discontinue nursing or discontinue tobramycin ophthalmic preparations, taking into account the importance of the drug to the woman.
The manufacturers state that caution is advised if fixed-combination ophthalmic preparations containing tobramycin and a corticosteroid are used in nursing women.
No enhanced messaging available.
ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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