Efudex (fluorouracil)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Fluorouracil, a fluorinated pyrimidine antagonist, acts as an antimetabolite interfering with DNA synthesis.
Fluorouracil is used topically for the treatment of multiple actinic (solar) keratoses; curettage or cryotherapy is preferred for the treatment of isolated lesions.
Generic name: fluorouracil
Pronunciation: (flewr-oh-YOUR-uh-sill)
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Efudex
Indications
The following indications are listed for Efudex:
- Actinic Keratosis
- Superficial Basal Cell Carcinoma
Also known as: Actinic Keratiasis, Keratiasis Senilis, Keratoma Senile, Keratosis Senilis, Senile Hyperkeratosis, Senile Keratiasis, Senile Keratoderma, Senile Keratoma, Senile Keratosis, Senile Wart, Solar Keratiasis, Solar Keratosis, Superficial Basal Cell Epithelioma, Superficial Basalioma, Superficial Bcc, Superficial Bce, Verruca Plana Senilis, Verruca Senilis.
Dosing
At equivalent concentrations, the solutions are considered more effective than the creams.
Fluorouracil cream or solution is applied topically with a nonmetallic applicator, clean fingertips, or gloved fingers in an amount sufficient to cover the lesions. If the fingers are used to apply the drug, the hands should be washed immediately afterward.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
No enhanced messaging available.
No enhanced messaging available.
Safe use of fluorouracil topical solution or cream during pregnancy has not been established.
No enhanced messaging available.
No enhanced messaging available.
ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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