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Isordil Titradose (isosorbide dinitrate)

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Last reviewed · Source: First Databank (FDB) drug data

Overview

Isosorbide dinitrate and isosorbide mononitrate, organic nitrates, are vasodilating agents.

USES: Isosorbide dinitrate is used to prevent chest pain (angina) in patients with a certain heart condition (coronary artery disease). This medication belongs to a class of drugs known as nitrates. It works by relaxing and widening blood vessels so blood can flow more easily to the heart.

This medication will not relieve chest pain once it occurs. It is also not intended to be taken just before physical activities (such as exercise, sexual activity) to prevent chest pain. Other medications may be needed in these situations.

Consult your doctor for more details.

Generic name: isosorbide dinitrate
Pronunciation: (EYE-soe-SOR-bide dye-NYE-trate)

Reference product & biosimilars

No reference, biosimilar or interchangeable associated with this drug.

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Indications

The following indications are listed for Isordil Titradose:

  • Prevention Of Anginal Pain Associated With Coronary Artery Disease

Also known as: Prevention Of Anginal Pain Associated With Cad.

Dosing

Dosage of isosorbide dinitrate and isosorbide mononitrate must be carefully adjusted according to the patient's requirements and response and the smallest effective dosage should be used.

When isosorbide dinitrate is used in fixed combination with hydralazine, the cautions, precautions, and contraindications associated with hydralazine must be considered in addition to those associated with isosorbide dinitrate (see Cautions and Precautions and Contraindications in the Nitrates and Nitrites General Statement 24:12.08).

Clinical studies of isosorbide dinitrate alone or in fixed combination with hydralazine did not include sufficient numbers of patients 65 years of age and older to determine whether geriatric patients respond differently than younger patients. Although other clinical experience has not revealed age-related differences in response or tolerance, drug dosage generally should be titrated carefully in geriatric patients, usually initiating therapy at the low end of the dosage range. The greater frequency of decreased hepatic, renal, and/or cardiac function and of concomitant disease and drug therapy observed in the elderly also should be considered. Elimination of isosorbide dinitrate and its metabolites may occur more slowly in geriatric patients than in younger adults.

Clinical studies of isosorbide mononitrate did not include sufficient numbers of patients 65 years of age and older to determine whether geriatric patients respond differently than younger patients. Other clinical experience has not identified any differences in responses between geriatric and younger patients. One manufacturer of isosorbide mononitrate states that if isosorbide mononitrate is used in geriatric patients, dosage of the drug should be selected with caution, usually initiating therapy at the low end of the dosage range, although age, renal, hepatic, and cardiovascular dysfunction do not appear to have a significant effect on the clearance of the drug.

Drug interactions

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Contraindications

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Adverse reactions

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Precautions

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ICD codes

No ICD codes are available for this drug.

Formulary status

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Last reviewed · Source: First Databank (FDB) drug data