Motofen (difenoxin HCl/atropine sulfate)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Atropine (dl-hyoscyamine) is a naturally occurring tertiary amine antimuscarinic.
USES: This medication is used to treat diarrhea. It helps to decrease the number and frequency of bowel movements. It works by slowing the movement of the intestines.
Difenoxin is similar to opioid pain relievers, but it acts mainly to slow the gut. Atropine belongs to a class of drugs known as anticholinergics, which help to dry up body fluids and also slow gut movement. This medication should not be used to treat diarrhea caused by certain types of infection (such as C. difficile-associated diarrhea following antibiotic therapy).
Talk to your doctor for more details. This drug is not recommended for use in children younger than 2 years due to an increased risk of very serious side effects.
Generic name: difenoxin HCl/atropine sulfate
Pronunciation: (DYE-fen-OX-in/AT-roe-peen)
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Motofen
Indications
The following indications are listed for Motofen:
- Diarrhea
Dosing
Dosage of atropine sulfate should be individualized based on indication, patient characteristics, and response (e.g., heart rate, blood pressure); pediatric patients tend to be more susceptible than adults to the toxic effects of atropine overdosage.
Atropine sulfate is administered by IM, subcutaneous, or direct IV administration. IV administration is preferred for the treatment of severe or life-threatening muscarinic effects.
Atropine also has been administered by intraosseous (IO) injection+ in the setting of advanced cardiovascular life support (ACLS), generally when IV access is not readily available; onset of action and systemic concentrations are comparable to those achieved with venous administration.
Atropine may be administered via an endotracheal tube when vascular access (IV or IO) is not possible; however, IV or IO administration is preferred because of more predictable drug delivery and pharmacologic effect. (See Pharmacokinetics: Absorption.)
Atropine sulfate has been administered orally; however, an oral dosage form no longer is commercially available in the US.
Atropine sulfate has been administered by oral inhalation using a nebulizer solution; however, a solution for oral inhalation no longer is commercially available in the US.
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Drug interactions
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There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
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Contraindications
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There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
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There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
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ICD codes
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Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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