Chlorpromazine Hcl (chlorpromazine HCl)

Dosage of chlorpromazine hydrochloride is expressed in terms of the hydrochloride salt.

The manufacturers state that the 100- and 200-mg tablets of chlorpromazine hydrochloride are intended for use in patients with severe neuropsychiatric conditions.

Dosage must be carefully adjusted according to individual requirements and response, using the lowest possible effective dosage. Dosage should be increased more gradually in debilitated, emaciated, or geriatric patients. Since geriatric patients may be more susceptible to hypotension and neuromuscular reactions, these patients should be observed closely; in general, dosages in the lower end of the range are sufficient for most geriatric patients. Because of the risk of adverse reactions associated with cumulative effects of phenothiazines, patients with a history of long-term therapy with chlorpromazine and/or other antipsychotic agents should be evaluated periodically to determine whether maintenance dosage should be decreased or drug therapy discontinued. Chlorpromazine should generally not be used in children younger than 6 months of age unless the condition to be treated is potentially life-threatening; dosage in this age group has not been established.

Chlorpromazine hydrochloride may be administered orally, by deep IM or direct IV injection, or by IV infusion. Direct IV injection is intended for use only during surgery to control nausea and vomiting and in the adjunctive treatment of tetanus. IV infusion is only intended for use in the adjunctive treatment of intractable hiccups in adults. Subcutaneous administration of the drug is not recommended because of local irritation. Parenteral therapy should be reserved for recumbent patients; however, if cautions are taken to avoid orthostatic hypotension (i.e., patient remains recumbent for at least 30 minutes after injection), acutely agitated ambulatory patients may receive the drug IM.

For IM administration, injection should be made slowly, deep into a large muscle mass such as the upper outer quadrant of the gluteus maximus; if irritation at the IM injection site is a problem, the drug can be diluted with 0.9% sodium chloride injection or 2% procaine hydrochloride. For direct IV injection, chlorpromazine hydrochloride injection should be diluted with 0.9% sodium chloride injection to a concentration not exceeding 1 mg/mL and administered at a rate of 1 mg/minute in adults and 0.5 mg/minute in children. IV administration of undiluted chlorpromazine hydrochloride injection should be avoided. For IV infusion, chlorpromazine hydrochloride injection should be added to 500-1000 mL of 0.9% sodium chloride injection and administered slowly.

No dosing information is available for this tab.

No dosing information is available for this tab.

There is no enhanced messaging for this drug.

There are no contraindication interactions for this drug.

There are no severe interactions for this drug.

There are no moderate interactions for this drug.

There is no enhanced messaging for this drug.

There are no contraindication contraindications for this drug.

There are no severe contraindications for this drug.

There are no moderate contraindications for this drug.

There is no enhanced messaging for this drug.

There are no severe adverse reactions for this drug.

There are no less severe adverse reactions for this drug.

No enhanced messaging available.

No enhanced messaging available.

No enhanced messaging available.

No enhanced messaging available.

No enhanced messaging available.