Oxytocin (oxytocin)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Oxytocin, a nonapeptide hormone secreted by the neurons of the supraoptic and paraventricular nuclei of the hypothalamus and stored in the posterior pituitary (neurohypophysis) in mammals, indirectly stimulates contraction of uterine smooth muscle.
Generic name: oxytocin
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Oxytocin
Indications
The following indications are listed for Oxytocin:
- Abortion
- Incomplete Abortion
- Induction Of Labor
- Postpartum Hemorrhage
Also known as: Postpartum Bleeding, Termination Of Pregnancy.
Dosing
No dosing information is available for this tab.
As an oxytocic, oxytocin should be given by IV infusion using a controlled-infusion device. Although oxytocin has been given IM, most clinicians believe this route of administration should not be used for augmentation or induction of labor because the effects it produces are unpredictable and difficult to control.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
Severe hypertension has been reported when oxytocin was given 3-4 hours following prophylactic administration of a vasoconstrictor in conjunction with caudal block anesthesia. Cyclopropane anesthesia may modify oxytocin's cardiovascular effects, producing less pronounced tachycardia but more severe hypotension than occurs with oxytocin alone; maternal sinus bradycardia with abnormal atrioventricular rhythms has been noted when oxytocin was used concomitantly with cyclopropane anesthesia. Oxytocin reportedly has delayed induction of thiopental (no longer commercially available in the US) anesthesia by producing venous spasm that caused peripheral pooling of thiopental; however, this interaction has not been conclusively established.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
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No enhanced messaging available.
Animal reproduction studies have not been performed with oxytocin; however, the manufacturers state that the drug is not indicated for use during the first or second trimester of pregnancy other than in relation to spontaneous or induced abortion. Based on wide experience with oxytocin and on its chemical and pharmacologic properties, the drug would not be expected to cause fetal abnormalities when used as indicated. Oxytocin can, however, cause nonteratogenic adverse effects. (See Cautions: Adverse Effects.)
Oxytocin may be distributed in small quantities into milk. If oxytocin therapy is required postpartum (e.g., to control severe bleeding), commencement of nursing should be delayed for at least 1 day after the drug has been discontinued.
No enhanced messaging available.
ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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