Dyna-Hex (ISOPROPYL ALCOHOL) (chlorhexidine gluconate/isopropyl alcohol)

Pending revision, the material in this section should be considered in light of more recently available information in the MedWatch notification at the beginning of this monograph.

Chlorhexidine gluconate 2 and 4% solutions in a sudsing base (skin cleanser) and chlorhexidine gluconate 0.5 and 1% solutions in an alcohol base with emollients (hand rub) are applied topically to the skin and hands. These topical preparations are for external use only, and contact with the eyes, ears, or mouth should be avoided. Chlorhexidine gluconate 2 and 4% solutions in a sudsing base should not be used for preoperative skin preparation on the face or head. Dressings containing chlorhexidine gluconate 20% are applied topically at the site of vascular and nonvascular percutaneous devices.

No dosing information is available for this tab.

No dosing information is available for this tab.

There is no enhanced messaging for this drug.

There are no contraindication interactions for this drug.

There are no severe interactions for this drug.

There are no moderate interactions for this drug.

There is no enhanced messaging for this drug.

There are no contraindication contraindications for this drug.

There are no severe contraindications for this drug.

There are no moderate contraindications for this drug.

There is no enhanced messaging for this drug.

There are no severe adverse reactions for this drug.

There are no less severe adverse reactions for this drug.

No enhanced messaging available.

No enhanced messaging available.

Reproduction studies in rats using chlorhexidine given by gastric lavage on days 6-15 of gestation have not revealed evidence of harm to the fetus. There are no adequate and controlled studies to date using chlorhexidine gluconate in pregnant women, and the drug should be used during pregnancy only when clearly needed.

It is not known if chlorhexidine gluconate is distributed into breast milk; however, is unlikely that chlorhexidine gluconate distributes into milk following topical or intravaginal application, based on the very small amount of the drug absorbed percutaneously into maternal circulation. Although the drug is poorly absorbed from the GI tract, if chlorhexidine gluconate has been used for skin cleansing, the mother's nipples should be washed thoroughly with water prior to nursing. One neonate was reported to develop multiple episodes of bradycardia and cyanosis, with serum chlorhexidine concentrations of 11 ng/mL after oral exposure when chlorhexidine gluconate was used on the mother's breasts to prevent mastitis.

No enhanced messaging available.