SYNRIBO (omacetaxine mepesuccinate)
ACCELERATED PHASE CHRONIC MYELOCYTIC LEUKEMIA·+1
CEPHALON,INC.
Indication
Accelerated phase chronic myelocytic leukemia
Accelerated phase chronic myelocytic leukemia (also termed accelerated phase chronic myeloid leukemia, or CML-AP) represents an intermediate, progressive stage of a clonal hematopoietic stem cell neoplasm defined by the *BCR::ABL1* fusion oncogene resulting from the Philadelphia chromosome. Read more about Accelerated phase chronic myelocytic leukemia
4 drugs 4 manufacturers
Drugs that treat it
Common Accelerated phase chronic myelocytic leukemia therapies.
ICLUSIG (ponatinib HCl)
BLASTIC PHASE CHRONIC MYELOID LEUKEMIA·+3
ARIAD PHARMACEU
ICLUSIG (ponatinib HCl)
BLASTIC PHASE CHRONIC MYELOID LEUKEMIA·+3
ARIAD/TAKEDA
ICLUSIG (ponatinib HCl)
ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·BLASTIC PHASE CHRONIC MYELOID LEUKEMIA·+3
MILLENNIUM PHAR
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Coming soonRelated conditions & guidelines
Coming soonAccelerated phase chronic myelocytic leukemia (also termed accelerated phase chronic myeloid leukemia, or CML-AP) represents an intermediate, progressive stage of a clonal hematopoietic stem cell neoplasm defined by the *BCR::ABL1* fusion oncogene resulting from the Philadelphia chromosome.
Predominantly affecting adults, the disease involves the bone marrow and peripheral blood, where dysregulated myeloproliferation escalates toward transformation into acute leukemia (blast crisis).
Defining pathophysiologic and diagnostic features include an increasing blast burden (typically 10% to 19% blasts in the peripheral blood or bone marrow), persistent peripheral basophilia (=20%), treatment-unresponsive worsening splenomegaly or leukocytosis, persistent thrombocytopenia or thrombocytosis, and the acquisition of additional cytogenetic abnormalities in Philadelphia chromosome-positive clones.
- nih.gov
Accelerated phase chronic myelocytic leukemia (also termed accelerated phase chronic myeloid leukemia, or CML-AP) represents an intermediate, progressive stage of a clonal hematopoietic stem cell neoplasm defined by the *BCR::ABL1* fusion oncogene resulting from the Philadelphia chromosome
- vacancer.com
Accelerated phase chronic myelocytic leukemia (also termed accelerated phase chronic myeloid leukemia, or CML-AP) represents an intermediate, progressive stage of a clonal hematopoietic stem cell neoplasm defined by the *BCR::ABL1* fusion oncogene resulting from the Philadelphia chromosome Defining pathophysiologic and diagnostic features include an increasing blast burden (typically 10% to 19% blasts in the peripheral blood or bone marrow), persistent peripheral basophilia (≥20%), treatment-unr...
- cancer.gov
Predominantly affecting adults, the disease involves the bone marrow and peripheral blood, where dysregulated myeloproliferation escalates toward transformation into acute leukemia (blast crisis)
- healthline.com
Predominantly affecting adults, the disease involves the bone marrow and peripheral blood, where dysregulated myeloproliferation escalates toward transformation into acute leukemia (blast crisis)
- cancer.gov
Defining pathophysiologic and diagnostic features include an increasing blast burden (typically 10% to 19% blasts in the peripheral blood or bone marrow), persistent peripheral basophilia (≥20%), treatment-unresponsive worsening splenomegaly or leukocytosis, persistent thrombocytopenia or thrombocytosis, and the acquisition of additional cytogenetic abnormalities in Philadelphia chromosome-positive clones
- nih.gov
Defining pathophysiologic and diagnostic features include an increasing blast burden (typically 10% to 19% blasts in the peripheral blood or bone marrow), persistent peripheral basophilia (≥20%), treatment-unresponsive worsening splenomegaly or leukocytosis, persistent thrombocytopenia or thrombocytosis, and the acquisition of additional cytogenetic abnormalities in Philadelphia chromosome-positive clones
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