Indication

Actinic keratosis of the upper extremity

Actinic keratosis of the upper extremity refers to a precancerous cutaneous lesion occurring on chronically sun-exposed areas of the arms, forearms, or dorsal hands. Read more about Actinic keratosis of the upper extremity

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About Actinic keratosis of the upper extremity.

Actinic keratosis of the upper extremity refers to a precancerous cutaneous lesion occurring on chronically sun-exposed areas of the arms, forearms, or dorsal hands.

Arising within the integumentary system, this condition primarily affects older adults and individuals with fair skin types who have sustained cumulative ultraviolet radiation damage.

Pathophysiologically, ultraviolet-induced DNA damage leads to the clonal proliferation of atypical epidermal keratinocytes, placing lesions at risk for progression to invasive cutaneous squamous cell carcinoma.

Clinically, these lesions present as gritty, rough-textured, erythematous, or hyperkeratotic macules, papules, or plaques that are frequently easier to identify by palpation than inspection.

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