Adult-onset Still's disease

Adult-onset Still's disease (AOSD) is a rare, systemic autoinflammatory disorder of unknown etiology that primarily affects young adults Additional hallmark systemic features include sore throat, lymphadenopathy, hepatosplenomegaly, serositis, and profound laboratory abnormalities such as marked leukocytosis and extreme hyperferritinemia

Adult-onset Still's disease (AOSD) is a rare, systemic autoinflammatory disorder of unknown etiology that primarily affects young adults Pathophysiologically, it is characterized by innate immune dysregulation marked by hyperactivation of macrophages and neutrophils alongside excessive production of proinflammatory cytokines, including interleukin-1 (IL-1), interleukin-6 (IL-6), and interleukin-18 (IL-18)

The condition classically manifests with a clinical triad of daily spiking quotidian fevers, an evanescent salmon-pink maculopapular rash, and inflammatory arthralgias or arthritis

The condition classically manifests with a clinical triad of daily spiking quotidian fevers, an evanescent salmon-pink maculopapular rash, and inflammatory arthralgias or arthritis

The condition classically manifests with a clinical triad of daily spiking quotidian fevers, an evanescent salmon-pink maculopapular rash, and inflammatory arthralgias or arthritis Additional hallmark systemic features include sore throat, lymphadenopathy, hepatosplenomegaly, serositis, and profound laboratory abnormalities such as marked leukocytosis and extreme hyperferritinemia

Additional hallmark systemic features include sore throat, lymphadenopathy, hepatosplenomegaly, serositis, and profound laboratory abnormalities such as marked leukocytosis and extreme hyperferritinemia