DARZALEX FASPRO (daratumumab-hyaluronidase-fihj)
ANTINEOPLASTIC - ANTI-CD38 MONOCLONAL ANTIBODY·MULTIPLE MYELOMA·+2
JANSSEN BIOTECH, Inc.
Indication
Amyloid light-chain amyloidosis
Amyloid light-chain amyloidosis is a rare, systemic protein-misfolding disorder caused by an underlying clonal plasma cell dyscrasia. Read more about Amyloid light-chain amyloidosis
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Coming soonAmyloid light-chain amyloidosis is a rare, systemic protein-misfolding disorder caused by an underlying clonal plasma cell dyscrasia.
The disease primarily affects older adults and is characterized by the overproduction of monoclonal immunoglobulin light chains that misfold into insoluble fibrillar deposits within the extracellular space of various organs.
Pathologic accumulation most frequently targets the heart and kidneys, although the peripheral nervous system, gastrointestinal tract, liver, and soft tissues are often involved.
Clinically, this process manifests as progressive multisystem organ dysfunction, prominently presenting with restrictive cardiomyopathy, nephrotic-range proteinuria, autonomic or peripheral neuropathy, and hepatomegaly.
- nih.gov
Amyloid light-chain amyloidosis is a rare, systemic protein-misfolding disorder caused by an underlying clonal plasma cell dyscrasia
- nih.gov
Amyloid light-chain amyloidosis is a rare, systemic protein-misfolding disorder caused by an underlying clonal plasma cell dyscrasia The disease primarily affects older adults and is characterized by the overproduction of monoclonal immunoglobulin light chains that misfold into insoluble fibrillar deposits within the extracellular space of various organs Pathologic accumulation most frequently targets the heart and kidneys, although the peripheral nervous system, gastrointestinal tract, liver, a...
- nih.gov
The disease primarily affects older adults and is characterized by the overproduction of monoclonal immunoglobulin light chains that misfold into insoluble fibrillar deposits within the extracellular space of various organs
- clevelandclinic.org
The disease primarily affects older adults and is characterized by the overproduction of monoclonal immunoglobulin light chains that misfold into insoluble fibrillar deposits within the extracellular space of various organs
- mayoclinic.org
Pathologic accumulation most frequently targets the heart and kidneys, although the peripheral nervous system, gastrointestinal tract, liver, and soft tissues are often involved
- nih.gov
Clinically, this process manifests as progressive multisystem organ dysfunction, prominently presenting with restrictive cardiomyopathy, nephrotic-range proteinuria, autonomic or peripheral neuropathy, and hepatomegaly
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