Anaplastic lymphoma kinase (ALK)-positive systemic anaplastic large cell lymphoma

Anaplastic lymphoma kinase (ALK)-positive systemic anaplastic large cell lymphoma is an aggressive subtype of mature peripheral T-cell non-Hodgkin lymphoma that primarily involves the lymphatic system and frequently presents at advanced stages with extranodal disease and B symptoms It predominantly affects children and young adults, showing a slight male predominance Morphologically, the neoplasm is characterized by large, pleomorphic lymphoid cells—often displaying kidney- or horseshoe-shaped n...

Anaplastic lymphoma kinase (ALK)-positive systemic anaplastic large cell lymphoma is an aggressive subtype of mature peripheral T-cell non-Hodgkin lymphoma that primarily involves the lymphatic system and frequently presents at advanced stages with extranodal disease and B symptoms

It predominantly affects children and young adults, showing a slight male predominance

Pathophysiologically, the disease is driven by aberrant expression of the ALK receptor tyrosine kinase, most commonly resulting from a recurrent t(2;5)(p23;q35) chromosomal translocation that fuses the *ALK* and *NPM1* genes Morphologically, the neoplasm is characterized by large, pleomorphic lymphoid cells—often displaying kidney- or horseshoe-shaped nuclei known as hallmark cells—that demonstrate uniform, strong surface expression of CD30

Pathophysiologically, the disease is driven by aberrant expression of the ALK receptor tyrosine kinase, most commonly resulting from a recurrent t(2;5)(p23;q35) chromosomal translocation that fuses the *ALK* and *NPM1* genes