Antithrombin III deficiency

Antithrombin III deficiency is a rare thrombophilic disorder of the hematologic and vascular systems characterized by inadequate levels or impaired function of antithrombin, a key natural anticoagulant glycoprotein The condition can be hereditary, stemming from pathogenic variants in the *SERPINC1* gene, or acquired secondary to decreased hepatic synthesis, excessive renal protein loss, consumptive coagulopathies, or critical illness Pathophysiologically, the loss of antithrombin-mediated neutra...

Antithrombin III deficiency is a rare thrombophilic disorder of the hematologic and vascular systems characterized by inadequate levels or impaired function of antithrombin, a key natural anticoagulant glycoprotein Consequently, affected individuals have a markedly heightened susceptibility to recurrent venous thromboembolism, most commonly presenting as deep vein thrombosis and pulmonary embolism

The condition can be hereditary, stemming from pathogenic variants in the *SERPINC1* gene, or acquired secondary to decreased hepatic synthesis, excessive renal protein loss, consumptive coagulopathies, or critical illness

Consequently, affected individuals have a markedly heightened susceptibility to recurrent venous thromboembolism, most commonly presenting as deep vein thrombosis and pulmonary embolism