JYNARQUE (tolvaptan)
ANTIDIURETIC HORMONE ANTAGONISTS·AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE
Otsuka Pharmaceutical Co., Ltd.
Indication
Autosomal dominant polycystic kidney disease
Autosomal dominant polycystic kidney disease is an inherited multisystem disorder primarily affecting the renal and cardiovascular systems, typically manifesting clinically in adulthood. Read more about Autosomal dominant polycystic kidney disease
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Coming soonAutosomal dominant polycystic kidney disease is an inherited multisystem disorder primarily affecting the renal and cardiovascular systems, typically manifesting clinically in adulthood.
It is pathologically driven by mutations in genes such as *PKD1* or *PKD2*, which lead to aberrant tubular epithelial cell proliferation and fluid secretion.
This causes the progressive, bilateral formation and enlargement of fluid-filled renal cysts that disrupt kidney architecture, resulting in flank pain, early-onset hypertension, hematuria, and a gradual decline toward end-stage renal disease.
Significant extrarenal manifestations also frequently occur, including hepatic cysts, cerebral intracranial aneurysms, and cardiac valvular abnormalities.
- medlineplus.gov
Autosomal dominant polycystic kidney disease is an inherited multisystem disorder primarily affecting the renal and cardiovascular systems, typically manifesting clinically in adulthood This causes the progressive, bilateral formation and enlargement of fluid-filled renal cysts that disrupt kidney architecture, resulting in flank pain, early-onset hypertension, hematuria, and a gradual decline toward end-stage renal disease Significant extrarenal manifestations also frequently occur, including h...
- nih.gov
Autosomal dominant polycystic kidney disease is an inherited multisystem disorder primarily affecting the renal and cardiovascular systems, typically manifesting clinically in adulthood It is pathologically driven by mutations in genes such as *PKD1* or *PKD2*, which lead to aberrant tubular epithelial cell proliferation and fluid secretion This causes the progressive, bilateral formation and enlargement of fluid-filled renal cysts that disrupt kidney architecture, resulting in flank pain, early...
- nih.gov
It is pathologically driven by mutations in genes such as *PKD1* or *PKD2*, which lead to aberrant tubular epithelial cell proliferation and fluid secretion
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