Bullous pemphigoid

Bullous pemphigoid is a chronic autoimmune subepidermal blistering dermatosis that predominantly affects older adults, typically those over 60 to 70 years of age It is primarily mediated by circulating IgG autoantibodies directed against hemidesmosomal structural antigens—specifically BP180 and BP230—at the dermoepidermal junction, which triggers complement activation, inflammatory cell recruitment, and tissue separation

Bullous pemphigoid is a chronic autoimmune subepidermal blistering dermatosis that predominantly affects older adults, typically those over 60 to 70 years of age Clinically, the condition manifests with severe pruritus alongside tense, fluid-filled bullae and erosions arising on normal-appearing, urticarial, or erythematous skin, most commonly involving the flexural extremities and lower abdomen

It is primarily mediated by circulating IgG autoantibodies directed against hemidesmosomal structural antigens—specifically BP180 and BP230—at the dermoepidermal junction, which triggers complement activation, inflammatory cell recruitment, and tissue separation Mucosal membrane involvement can occur, though it is usually mild and less prominent than cutaneous disease

It is primarily mediated by circulating IgG autoantibodies directed against hemidesmosomal structural antigens—specifically BP180 and BP230—at the dermoepidermal junction, which triggers complement activation, inflammatory cell recruitment, and tissue separation Clinically, the condition manifests with severe pruritus alongside tense, fluid-filled bullae and erosions arising on normal-appearing, urticarial, or erythematous skin, most commonly involving the flexural extremities and lower abdomen