Indication

Candidal endocarditis

Candidal endocarditis is a severe, life-threatening fungal infection of the endocardium, most commonly involving native or prosthetic cardiac valves, implantable cardiac devices, or mural endocardium. Read more about Candidal endocarditis

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About Candidal endocarditis.

Candidal endocarditis is a severe, life-threatening fungal infection of the endocardium, most commonly involving native or prosthetic cardiac valves, implantable cardiac devices, or mural endocardium.

Primarily caused by *Candida albicans* or non-albicans *Candida* species such as *Candida parapsilosis*, it typically develops following candidemia in vulnerable populations, including patients with prosthetic heart valves, prolonged central venous catheterization, immunosuppression, or a history of injection drug use.

Pathophysiologically, the yeast adheres to damaged endothelial or prosthetic surfaces and forms robust, biofilm-laden vegetations that are characteristically bulky and prone to fragmentation.

Clinical manifestations range from indolent fever, heart murmurs, and progressive heart failure to acute valvular destruction, perivalvular abscesses, and high rates of major arterial embolic complications.

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