CCR5 tropic HIV infection

CCR5-tropic HIV infection is a human immunodeficiency virus infection characterized specifically by viral strains (termed R5-tropic) that rely exclusively on the host C-C chemokine receptor type 5 (CCR5) as a coreceptor alongside CD4 for cellular entry This viral phenotype primarily targets the human immune system, specifically infecting CD4+ T lymphocytes, macrophages, and dendritic cells, and it represents the predominant form of HIV involved in initial transmission and early-stage disease

This viral phenotype primarily targets the human immune system, specifically infecting CD4+ T lymphocytes, macrophages, and dendritic cells, and it represents the predominant form of HIV involved in initial transmission and early-stage disease

This viral phenotype primarily targets the human immune system, specifically infecting CD4+ T lymphocytes, macrophages, and dendritic cells, and it represents the predominant form of HIV involved in initial transmission and early-stage disease

Clinically defined through phenotypic or genotypic tropism assays confirming the absence of CXCR4-using or dual/mixed-tropic virus, this specific clinical state identifies patients whose infection can be selectively targeted by host-directed viral entry inhibitors

Clinically defined through phenotypic or genotypic tropism assays confirming the absence of CXCR4-using or dual/mixed-tropic virus, this specific clinical state identifies patients whose infection can be selectively targeted by host-directed viral entry inhibitors