Chemotherapy-induced mucositis

Chemotherapy-induced mucositis is a frequent and dose-limiting toxic complication of cytotoxic cancer therapy, characterized by acute inflammation, tissue damage, and ulceration along the mucosal lining of the gastrointestinal tract It most commonly manifests as oral or intestinal mucositis in oncology patients receiving conventional antineoplastic regimens or high-dose conditioning therapy for hematopoietic stem cell transplantation Pathophysiologically, cytotoxic agents trigger DNA damage, gen...

Chemotherapy-induced mucositis is a frequent and dose-limiting toxic complication of cytotoxic cancer therapy, characterized by acute inflammation, tissue damage, and ulceration along the mucosal lining of the gastrointestinal tract Pathophysiologically, cytotoxic agents trigger DNA damage, generate reactive oxygen species, and initiate a cascade of pro-inflammatory cytokines that disrupt the basal epithelial renewal cycle, causing mucosal atrophy, loss of barrier integrity, and painful ulcerati...

Chemotherapy-induced mucositis is a frequent and dose-limiting toxic complication of cytotoxic cancer therapy, characterized by acute inflammation, tissue damage, and ulceration along the mucosal lining of the gastrointestinal tract Clinically, affected patients experience severe pain, dysphagia, malnutrition, and diarrhea, along with an elevated risk of systemic infection and bacteremia secondary to mucosal barrier breakdown during periods of neutropenia

It most commonly manifests as oral or intestinal mucositis in oncology patients receiving conventional antineoplastic regimens or high-dose conditioning therapy for hematopoietic stem cell transplantation

Pathophysiologically, cytotoxic agents trigger DNA damage, generate reactive oxygen species, and initiate a cascade of pro-inflammatory cytokines that disrupt the basal epithelial renewal cycle, causing mucosal atrophy, loss of barrier integrity, and painful ulcerations