Cholera vaccination

Cholera vaccination is indicated for active immunization to prevent gastrointestinal disease caused by toxigenic *Vibrio cholerae* serogroup O1, primarily in pediatric and adult travelers visiting areas with active transmission The target infection is an acute secretory diarrheal illness occurring after ingestion of contaminated water or food, in which the bacterium colonizes the small intestine and secretes cholera enterotoxin This toxin causes hypersecretion of electrolytes and water, leading ...

Cholera vaccination is indicated for active immunization to prevent gastrointestinal disease caused by toxigenic *Vibrio cholerae* serogroup O1, primarily in pediatric and adult travelers visiting areas with active transmission

The target infection is an acute secretory diarrheal illness occurring after ingestion of contaminated water or food, in which the bacterium colonizes the small intestine and secretes cholera enterotoxin This toxin causes hypersecretion of electrolytes and water, leading to hallmark voluminous watery diarrhea, rapid extracellular volume depletion, hypovolemic shock, and severe metabolic acidosis Immunization stimulates mucosal and systemic antibody defenses to reduce the risk of clinical infecti...