Indication

Cholestatic pruritus in patients with Alagille syndrome

Cholestatic pruritus in patients with Alagille syndrome is a severe, chronic itching disorder arising as a major complication of Alagille syndrome, an autosomal dominant genetic condition predominantly affecting the hepatobiliary system. Read more about Cholestatic pruritus in patients with Alagille syndrome

4 drugs 3 manufacturers

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Drugs that treat it

Common Cholestatic pruritus in patients with Alagille syndrome therapies.

Showing 1–4 of 4 drugs

BYLVAY (odevixibat)

PRURITUS DUE TO PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS·+1
ALBIREO PHARMA

BYLVAY (odevixibat)

PRURITUS DUE TO PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS·+1
ALBIREO PHARMA

LIVMARLI (maralixibat chloride)

ILEAL BILE ACID TRANSPORTER (IBAT) INHIBITOR·PRURITUS DUE TO PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS·+1
MIRUM PHARMACEU

BYLVAY (odevixibat)

ILEAL BILE ACID TRANSPORTER (IBAT) INHIBITOR·PRURITUS DUE TO PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS·+1
IPSEN BIOPHARMA
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About Cholestatic pruritus in patients with Alagille syndrome.

Cholestatic pruritus in patients with Alagille syndrome is a severe, chronic itching disorder arising as a major complication of Alagille syndrome, an autosomal dominant genetic condition predominantly affecting the hepatobiliary system.

The underlying pathophysiology involves intrahepatic bile duct paucity leading to impaired bile flow and systemic retention of pruritogenic substances, particularly elevated serum bile acids, which stimulate sensory nerves in the skin.

Primarily observed in pediatric populations but also affecting adolescents and adults, this unremitting pruritus frequently leads to substantial secondary morbidity, including sleep deprivation, emotional distress, and skin excoriation or scarring caused by persistent, forceful scratching.

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