Chronic thromboembolic pulmonary hypertension

Chronic thromboembolic pulmonary hypertension is a rare, progressive form of precapillary pulmonary hypertension (classified as World Health Organization Group 4) that affects the pulmonary vascular bed and right heart Clinically, affected patients present with worsening exertional dyspnea, exercise intolerance, and fatigue, which can advance to overt right ventricular failure and premature death if untreated

It arises when single or recurrent pulmonary thromboemboli fail to resolve, transforming into organized, fibrotic material that obstructs the large elastic pulmonary arteries

It arises when single or recurrent pulmonary thromboemboli fail to resolve, transforming into organized, fibrotic material that obstructs the large elastic pulmonary arteries

It arises when single or recurrent pulmonary thromboemboli fail to resolve, transforming into organized, fibrotic material that obstructs the large elastic pulmonary arteries This mechanical obstruction, coupled with secondary microvascular remodeling in non-occluded vessels, progressively elevates pulmonary vascular resistance and pulmonary arterial pressure Clinically, affected patients present with worsening exertional dyspnea, exercise intolerance, and fatigue, which can advance to overt rig...

This mechanical obstruction, coupled with secondary microvascular remodeling in non-occluded vessels, progressively elevates pulmonary vascular resistance and pulmonary arterial pressure

Clinically, affected patients present with worsening exertional dyspnea, exercise intolerance, and fatigue, which can advance to overt right ventricular failure and premature death if untreated