Indication

Cluster headache prevention

Cluster headache prevention refers to prophylactic therapy aimed at reducing the frequency, severity, and duration of attacks in cluster headache, a severely disabling primary headache disorder categorized among the trigeminal autonomic cephalalgias. Read more about Cluster headache prevention

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About Cluster headache prevention.

Cluster headache prevention refers to prophylactic therapy aimed at reducing the frequency, severity, and duration of attacks in cluster headache, a severely disabling primary headache disorder categorized among the trigeminal autonomic cephalalgias.

The condition predominantly affects adults and involves dysfunction of the central nervous system, particularly the posterior hypothalamus, the trigeminovascular system, and parasympathetic autonomic pathways.

It is clinically characterized by excruciating, strictly unilateral pain centered in the orbital, supraorbital, or temporal regions.

These paroxysms are accompanied by ipsilateral cranial autonomic symptoms—such as lacrimation, conjunctival injection, ptosis, miosis, and nasal congestion—as well as marked agitation, recurring either in discrete cyclical bouts (episodic) or unremittingly without meaningful remission (chronic).

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