Congenital toxoplasmosis

Congenital toxoplasmosis is an infectious disease of the developing fetus or newborn resulting from transplacental transmission of the obligate intracellular protozoan *Toxoplasma gondii*, typically following an acute, primary maternal infection during pregnancy The parasite primarily damages the central nervous system, eyes, and reticuloendothelial system, causing pathology that ranges from asymptomatic subclinical infection to severe fetal morbidity or fetal demise

Congenital toxoplasmosis is an infectious disease of the developing fetus or newborn resulting from transplacental transmission of the obligate intracellular protozoan *Toxoplasma gondii*, typically following an acute, primary maternal infection during pregnancy

Congenital toxoplasmosis is an infectious disease of the developing fetus or newborn resulting from transplacental transmission of the obligate intracellular protozoan *Toxoplasma gondii*, typically following an acute, primary maternal infection during pregnancy

The parasite primarily damages the central nervous system, eyes, and reticuloendothelial system, causing pathology that ranges from asymptomatic subclinical infection to severe fetal morbidity or fetal demise Defining clinical features classically encompass the triad of chorioretinitis, hydrocephalus, and intracranial calcifications, frequently accompanied by microcephaly, seizures, sensorineural hearing loss, and systemic signs such as hepatosplenomegaly, jaundice, and thrombocytopenia

While transmission risk rises in later gestation, maternal infections acquired earlier in pregnancy typically correlate with more severe fetal disease and long-term neurocognitive impairment