Diabetes mellitus with severe insulin resistance

Diabetes mellitus with severe insulin resistance is an endocrine and metabolic disorder characterized by persistent hyperglycemia arising from a profound impairment in target tissue responsiveness to insulin Primarily affecting metabolic tissues including skeletal muscle, adipose tissue, and the liver, this clinical state occurs either as an extreme presentation of type 2 diabetes—often exacerbated by profound obesity—or secondary to rare genetic or autoimmune conditions such as lipodystrophy sy...

Diabetes mellitus with severe insulin resistance is an endocrine and metabolic disorder characterized by persistent hyperglycemia arising from a profound impairment in target tissue responsiveness to insulin Primarily affecting metabolic tissues including skeletal muscle, adipose tissue, and the liver, this clinical state occurs either as an extreme presentation of type 2 diabetes—often exacerbated by profound obesity—or secondary to rare genetic or autoimmune conditions such as lipodystrophy sy...

Primarily affecting metabolic tissues including skeletal muscle, adipose tissue, and the liver, this clinical state occurs either as an extreme presentation of type 2 diabetes—often exacerbated by profound obesity—or secondary to rare genetic or autoimmune conditions such as lipodystrophy syndromes, insulin receptor mutations, or anti-insulin receptor antibodies

It is clinically defined by marked endogenous hyperinsulinemia or exceptionally high exogenous insulin requirements, commonly exceeding 2 units per kilogram per day or 200 units daily, and frequently manifests with severe acanthosis nigricans, pronounced dyslipidemia, and hepatic steatosis

It is clinically defined by marked endogenous hyperinsulinemia or exceptionally high exogenous insulin requirements, commonly exceeding 2 units per kilogram per day or 200 units daily, and frequently manifests with severe acanthosis nigricans, pronounced dyslipidemia, and hepatic steatosis