Dupuytren's contracture

Dupuytren's contracture is a progressive fibroproliferative disorder of the connective tissue of the hand, characterized by pathologic thickening and shortening of the palmar and digital fascia The pathophysiology is driven by myofibroblast proliferation and excessive deposition of collagen, initially presenting as firm palmar nodules that evolve into inelastic fibrous cords Over time, these cords contract along lines of tension to produce fixed flexion deformities—most frequently involving the ...

Dupuytren's contracture is a progressive fibroproliferative disorder of the connective tissue of the hand, characterized by pathologic thickening and shortening of the palmar and digital fascia It most commonly affects older adults, with a higher prevalence in men and individuals of Northern European descent Over time, these cords contract along lines of tension to produce fixed flexion deformities—most frequently involving the metacarpophalangeal and proximal interphalangeal joints of the ring ...

It most commonly affects older adults, with a higher prevalence in men and individuals of Northern European descent

The pathophysiology is driven by myofibroblast proliferation and excessive deposition of collagen, initially presenting as firm palmar nodules that evolve into inelastic fibrous cords Over time, these cords contract along lines of tension to produce fixed flexion deformities—most frequently involving the metacarpophalangeal and proximal interphalangeal joints of the ring and little fingers—resulting in impaired extension and loss of hand function