Epithelial ovarian cancer with BRCA mutation

Epithelial ovarian cancer with a *BRCA* mutation refers to a malignant neoplasm arising from the epithelial surface of the ovary, fallopian tube, or primary peritoneum in patients harboring deleterious germline or somatic mutations in the *BRCA1* or *BRCA2* tumor suppressor genes Pathophysiologically, the loss of functional BRCA protein impairs homologous recombination repair of double-strand DNA breaks, resulting in genomic instability that drives malignant transformation while simultaneously c...

Epithelial ovarian cancer with a *BRCA* mutation refers to a malignant neoplasm arising from the epithelial surface of the ovary, fallopian tube, or primary peritoneum in patients harboring deleterious germline or somatic mutations in the *BRCA1* or *BRCA2* tumor suppressor genes This clinical biomarker subgroup most commonly presents in adult women as high-grade serous carcinoma, typically manifesting at advanced stages with peritoneal dissemination, ascites, and abdominal pelvic symptoms Conse...

This clinical biomarker subgroup most commonly presents in adult women as high-grade serous carcinoma, typically manifesting at advanced stages with peritoneal dissemination, ascites, and abdominal pelvic symptoms