Erythema nodosum leprosum

Erythema nodosum leprosum, also designated as a type 2 lepra reaction, is an acute or recurrent immune-mediated inflammatory complication occurring in patients with multibacillary forms of Hansen disease, primarily lepromatous and borderline lepromatous leprosy Clinically, it presents with painful, tender crops of erythematous subcutaneous nodules or plaques frequently accompanied by high fever, malaise, peripheral neuritis, arthralgias, lymphadenopathy, and potentially organ-threatening complic...

Erythema nodosum leprosum, also designated as a type 2 lepra reaction, is an acute or recurrent immune-mediated inflammatory complication occurring in patients with multibacillary forms of Hansen disease, primarily lepromatous and borderline lepromatous leprosy It affects the integumentary and nervous systems as well as multiple visceral organs, driven immunologically by circulating immune complex deposition, intense neutrophil infiltration, and systemic release of pro-inflammatory cytokines suc...

It affects the integumentary and nervous systems as well as multiple visceral organs, driven immunologically by circulating immune complex deposition, intense neutrophil infiltration, and systemic release of pro-inflammatory cytokines such as tumor necrosis factor-alpha Clinically, it presents with painful, tender crops of erythematous subcutaneous nodules or plaques frequently accompanied by high fever, malaise, peripheral neuritis, arthralgias, lymphadenopathy, and potentially organ-threatenin...

Clinically, it presents with painful, tender crops of erythematous subcutaneous nodules or plaques frequently accompanied by high fever, malaise, peripheral neuritis, arthralgias, lymphadenopathy, and potentially organ-threatening complications such as iridocyclitis or orchitis