Facial angiofibroma associated with tuberous sclerosis complex

Facial angiofibroma associated with tuberous sclerosis complex is a characteristic dermatologic manifestation of an autosomal dominant genetic neurocutaneous syndrome The condition arises from pathogenic loss-of-function variants in either the *TSC1* or *TSC2* genes, resulting in constitutive hyperactivation of the mechanistic target of rapamycin (mTOR) signaling pathway and dysregulated cellular proliferation Pathophysiologically classified as cutaneous hamartomas composed of dermal fibroplasia...

Facial angiofibroma associated with tuberous sclerosis complex is a characteristic dermatologic manifestation of an autosomal dominant genetic neurocutaneous syndrome

The condition arises from pathogenic loss-of-function variants in either the *TSC1* or *TSC2* genes, resulting in constitutive hyperactivation of the mechanistic target of rapamycin (mTOR) signaling pathway and dysregulated cellular proliferation

The condition arises from pathogenic loss-of-function variants in either the *TSC1* or *TSC2* genes, resulting in constitutive hyperactivation of the mechanistic target of rapamycin (mTOR) signaling pathway and dysregulated cellular proliferation Pathophysiologically classified as cutaneous hamartomas composed of dermal fibroplasia and dilated capillaries, these lesions can cause local bleeding, progressive aesthetic disfigurement, and notable psychosocial distress

Clinically, it typically develops in childhood and affects the majority of individuals with tuberous sclerosis complex, presenting as benign, pink-to-reddish vascular and fibrous papules or plaques symmetrically distributed across the nose, cheeks, and nasolabial folds

Clinically, it typically develops in childhood and affects the majority of individuals with tuberous sclerosis complex, presenting as benign, pink-to-reddish vascular and fibrous papules or plaques symmetrically distributed across the nose, cheeks, and nasolabial folds Pathophysiologically classified as cutaneous hamartomas composed of dermal fibroplasia and dilated capillaries, these lesions can cause local bleeding, progressive aesthetic disfigurement, and notable psychosocial distress

Clinically, it typically develops in childhood and affects the majority of individuals with tuberous sclerosis complex, presenting as benign, pink-to-reddish vascular and fibrous papules or plaques symmetrically distributed across the nose, cheeks, and nasolabial folds

Pathophysiologically classified as cutaneous hamartomas composed of dermal fibroplasia and dilated capillaries, these lesions can cause local bleeding, progressive aesthetic disfigurement, and notable psychosocial distress