ELAHERE (mirvetuximab soravtansine-gynx)
ANTINEOPLASTIC MONOCLONAL ANTIBODIES·FOLATE RECEPTOR ALPHA POSITIVE EPITHELIAL OVARIAN CANCER
IMMUNOGEN, INC.
Indication
Folate receptor alpha positive epithelial ovarian cancer
Folate receptor alpha-positive epithelial ovarian cancer is a molecularly defined subtype of malignant epithelial tumor arising in the female reproductive tract, including the ovaries, fallopian tubes, and peritoneum. Read more about Folate receptor alpha positive epithelial ovarian cancer
2 drugs 2 manufacturers
Drugs that treat it
Common Folate receptor alpha positive epithelial ovarian cancer therapies.
ELAHERE (mirvetuximab soravtansine-gynx)
ANTINEOPLASTIC MONOCLONAL ANTIBODIES·FOLATE RECEPTOR ALPHA POSITIVE EPITHELIAL OVARIAN CANCER
ABBOTT
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Coming soonFolate receptor alpha-positive epithelial ovarian cancer is a molecularly defined subtype of malignant epithelial tumor arising in the female reproductive tract, including the ovaries, fallopian tubes, and peritoneum.
It is characterized by high cell-surface overexpression of folate receptor alpha, a glycosylphosphatidylinositol-anchored protein involved in folate transport and cellular proliferation that is minimally expressed in most normal tissues.
Positivity is typically determined via validated immunohistochemical companion diagnostic assays, commonly defined by moderate-to-strong membrane staining in a substantial proportion of tumor cells.
Pathophysiologically common in high-grade serous histologies, this clinical biomarker status identifies patients whose tumors may respond to receptor-targeted therapeutics.
- fda.gov
Folate receptor alpha-positive epithelial ovarian cancer is a molecularly defined subtype of malignant epithelial tumor arising in the female reproductive tract, including the ovaries, fallopian tubes, and peritoneum
- frontiersin.org
Folate receptor alpha-positive epithelial ovarian cancer is a molecularly defined subtype of malignant epithelial tumor arising in the female reproductive tract, including the ovaries, fallopian tubes, and peritoneum
- nih.gov
It is characterized by high cell-surface overexpression of folate receptor alpha, a glycosylphosphatidylinositol-anchored protein involved in folate transport and cellular proliferation that is minimally expressed in most normal tissues Positivity is typically determined via validated immunohistochemical companion diagnostic assays, commonly defined by moderate-to-strong membrane staining in a substantial proportion of tumor cells Pathophysiologically common in high-grade serous histologies, thi...
- nih.gov
It is characterized by high cell-surface overexpression of folate receptor alpha, a glycosylphosphatidylinositol-anchored protein involved in folate transport and cellular proliferation that is minimally expressed in most normal tissues
- cancernetwork.com
Positivity is typically determined via validated immunohistochemical companion diagnostic assays, commonly defined by moderate-to-strong membrane staining in a substantial proportion of tumor cells
- mdpi.com
Pathophysiologically common in high-grade serous histologies, this clinical biomarker status identifies patients whose tumors may respond to receptor-targeted therapeutics
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